Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.58 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | USP7 | Q93009 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 2/20 | 0.56 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.54 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6798003 | 0.88 | ALDH1A1 (0.80) | ALDH1A1CYP17A1CYP11B1CYP11B2MAP4K4 | |
| SCHEMBL8577619 | 0.88 | SMN1; SMN2 (0.70) | ALDH1A1CYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL3786463 | 0.86 | NQO2 (0.73) | ALDH1A1CYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL12999591 | 0.85 | NPC1 (0.69) | ALDH1A1CYP17A1CYP11B1CYP11B2MAP4K4 | |
| SCHEMBL12919978 | 0.84 | CYP17A1 (0.60) | ALDH1A1CYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL14384612 | 0.83 | CNR1 (0.71) | CYP17A1CYP11B1CYP11B2HSD17B1HSD17B2 | |
| SCHEMBL969807 | 0.83 | RAB9A (0.65) | ALDH1A1CYP17A1CYP11B1CYP11B2MAP4K4 | |
| SCHEMBL6796771 | 0.83 | ALDH1A1 (0.67) | ALDH1A1CYP17A1CYP11B1CYP11B2MAP4K4 | |
| SCHEMBL1016291 | 0.83 | ALDH1A1 (0.57) | ALDH1A1CYP17A1CYP11B1CYP11B2MAP4K4 | |
| SCHEMBL3225408 | 0.82 | SMN1; SMN2 (0.79) | ALDH1A1MEN1KMT2AHSD17B10HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976842-B1 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH SPA (IT) | 2010-03-10 | — | — | EP | disclosed |
| EP-1991528-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | Siena Biotech S.p.A. (IT) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007098826-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2007-09-07 | — | — | WO | disclosed |