Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 known ✓ | P30411 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807201 | 0.73 | DNM1 (0.41) | DNM1CA2CA1ALDH1A1TDP1 | |
| SCHEMBL611894 | 0.73 | — | — | |
| SCHEMBL31284200 | 0.73 | DNM1 (0.41) | DNM1CA2CA1ALDH1A1TDP1 | |
| SCHEMBL2778416 | 0.71 | — | — | |
| SCHEMBL13864439 | 0.71 | — | — | |
| SCHEMBL7529330 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL3155694 | 0.69 | CA2 (0.38) | DNM1CA2CA1ALDH1A1TDP1 | |
| SCHEMBL13717637 | 0.69 | — | — | |
| SCHEMBL5708974 | 0.69 | DNM1 (0.38) | DNM1CA2CA1ALDH1A1TDP1 | |
| SCHEMBL17527008 | 0.69 | DNM1 (0.43) | DNM1CA2CA1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1634895-B1 | Fluoropolymer for making a fluoroelastomer | 3M INNOVATIVE PROPERTIES CO (US) | 2008-11-05 | — | — | EP | disclosed |
| US-7070842-B2 | Method of bonding a fluoroelastomer layer to a silicone rubber layer, laminate for use in said method and article produced therewith | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-07-04 | — | — | US | disclosed |
| WO-2006031316-A2 | FLUOROPOLYMER FOR MAKING A FLUOROELASTOMER | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-03-23 | — | — | WO | disclosed |
| EP-1634895-A1 | Fluoropolymer for making a fluoroelastomer | 3M Innovative Properties Company (US) | 2006-03-15 | — | — | EP | disclosed |
| US-20060052557-A1 | Fluoropolymer for making a fluoroelastomer | 3M INNOVATIVE PROPERTIES COMPANY | 2006-03-09 | — | — | US | disclosed |
| EP-1454740-B1 | Method of bonding a fluoroelastomer layer to a silicone rubber layer, laminate for use in said method and article produced therewith | 3M INNOVATIVE PROPERTIES CO (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004078470-A1 | METHOD OF BONDING A FLUOROELASTOMER LAYER TO A SILICONE RUBBER LAYER, LAMINATE FOR USE IN SAID METHOD AND ARTICLE PRODUCED THEREWITH | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2004-09-16 | — | — | WO | disclosed |
| US-20040175526-A1 | Method of bonding a fluoroelastomer layer to a silicone rubber layer, laminate for use in said method and article produced therewith | 3M INNOVATVE PROPERTIES COMPANY | 2004-09-09 | — | — | US | disclosed |
| EP-1454740-A1 | Method of bonding a fluoroelastomer layer to a silicone rubber layer, laminate for use in said method and article produced therewith | 3M Innovative Properties Company (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6447916-B1 | FLUOROPOLYMER DIRECTLY BONDED TO A SILICONE-CONTAINING POLYMER; FLUOROPOLYMER CAN PROVIDE A REACTIVE SITE THROUGH DEHYDROFLUORINATION OR BY INCORPORATING A REACTIVE MONOMER; PEROXIDE CURING/BONDING AGENT | DYNEON, LLC | 2002-09-10 | — | — | US | disclosed |
| EP-1112179-A1 | MULTILAYER COMPOSITES | DYNEON LLC (US) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000013891-A1 | MULTILAYER COMPOSITES | DYNEON LLC (US) | 2000-03-16 | — | — | WO | disclosed |