SCHEMBL465534

SCHEMBL465534

CCC(=O)Oc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1CCSCCc1c(OC(=O)CC)cc(C(C)(C)C)c(O)c1C(C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
VCAM1 P19320 11/20 0.36
ALOX15 P16050 3/20 0.35
LMNA P02545 1/20 0.33
RECQL P46063 1/20 0.33
PTGS1 P23219 1/20 0.32
GAA P10253 1/20 0.32
KMT2A Q03164 1/20 0.32
HMGCR P04035 1/20 0.32
GLRA3 O75311 1/20 0.32
GLRB P48167 1/20 0.32
ACHE P22303 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6345872 0.95 VCAM1 (0.34) VCAM1ALOX15LMNARECQLPTGS1
SCHEMBL29367920 0.84 ALOX5 (0.39) VCAM1GAA
SCHEMBL28701034 0.84 ALOX5 (0.39) VCAM1GAA
SCHEMBL526572 0.84 ALOX5 (0.39) VCAM1GAA
SCHEMBL28425957 0.84 ALOX5 (0.39) VCAM1GAA
SCHEMBL29096147 0.83 GAA (0.34) VCAM1ALOX15LMNARECQLGAA
SCHEMBL14840002 0.82 PTGS2 (0.41)
SCHEMBL14840246 0.82 PTGS2 (0.41)
SCHEMBL30488761 0.81 VCAM1 (0.40) VCAM1ALOX15LMNARECQLGAA
SCHEMBL4424910 0.81 ALOX15 (0.34) VCAM1ALOX15LMNARECQLGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8871834-B2 Stabilized polypropylene-talc composite BOREALIS AG (AU) 2014-10-28 US disclosed
US-8815987-B2 Polypropylene mineral compound with reduced volatiles BOREALIS AG (AT) 2014-08-26 US disclosed
US-8334330-B2 Reduction of volatiles of stabilized polypropylene/talc compositions by using specific acidic environment BOREALIS AG (AT) 2012-12-18 US disclosed
US-20120123033-A1 POLYPROPYLENE MINERAL COMPOUND WITH REDUCED VOLATILES BOREALIS AG (AT) 2012-05-17 US disclosed
US-20120088870-A1 Stabilized Polypropylene-Talc Composite BOREALIS AG (AT) 2012-04-12 US disclosed
EP-2433982-A1 Composition with low dissipation factor tan \"delta\ Borealis AG (AT) 2012-03-28 EP disclosed
EP-2240542-B9 LOW-STICKY ADDITIVE PACKAGE FOR AUTOMOTIVE INTERIOR APPLICATIONS BOREALIS AG (AT) 2012-01-11 EP disclosed
EP-2240542-B1 LOW-STICKY ADDITIVE PACKAGE FOR AUTOMOTIVE INTERIOR APPLICATIONS BOREALIS AG (AT) 2011-06-15 EP disclosed
EP-2141197-B1 Polypropylene composition with improved properties BOREALIS AG (AT) 2011-05-25 EP disclosed
US-20110118396-A1 REDUCTION OF VOLATILES OF STABILIZED POLYPROPYLENE/TALC COMPOSITIONS BY USING SPECIFIC ACIDIC ENVIRONMENT BOREALIS AG (AT) 2011-05-19 US disclosed
WO-2011023594-A1 POLYPROPYLENE-TALC COMPOSITE WITH REDUCED MALODOUR BOREALIS AG (AT) 2011-03-03 WO disclosed
EP-0038183-A1 Polyphenylene ether resin compositions and shaped articles thereof MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1981-10-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110118396-A1 REDUCTION OF VOLATILES OF STABILIZED POLYPROPYLENE/TALC COMPOSITIONS BY USING SPECIFIC ACIDIC ENVIRONMENT PPARA, VDAC1, BAX VCAM1 411/4885ALOX15 125/4885LMNA 262/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.