⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28257536 | 0.82 | — | — | |
| SCHEMBL27854797 | 0.79 | HRH3 (0.37) | — | |
| SCHEMBL5815987 | 0.77 | DHFR (0.40) | — | |
| SCHEMBL19514365 | 0.76 | — | — | |
| SCHEMBL28148645 | 0.76 | POLB (0.36) | — | |
| SCHEMBL22496974 | 0.74 | HTR1A (0.35) | — | |
| SCHEMBL34847 | 0.73 | — | — | |
| SCHEMBL2028609 | 0.73 | — | — | |
| SCHEMBL4654505 | 0.73 | — | — | |
| SCHEMBL4082503 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023111181-A1 | SMALL MOLECULE MODULATORS OF IL-17 | LEO PHARMA A/S (DK) | 2023-06-22 | — | — | WO | disclosed |
| CN-110167943-B | Pyrrolotriazine derivatives as kinase inhibitors | 株式会社大熊制药 | 2022-08-30 | — | — | CN | disclosed |
| US-11084823-B2 | Substituted pyrrolo[2,1-f][1,2,4]triazines as kinase inhibitors | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2021-08-10 | — | — | US | disclosed |
| US-RE48635-E1 | ERK inhibitors | ELI LILLY AND COMPANY (US) | 2021-07-13 | — | — | US | disclosed |
| US-RE48635-E1 | ERK inhibitors | ELI LILLY AND COMPANY (US) | 2021-07-13 | — | — | US | disclosed |
| US-20210130358-A1 | Pyrrolotriazine Derivatives as Kinase Inhibitor | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2021-05-06 | — | — | US | disclosed |
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |
| EP-3728238-A1 | SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS | Nodthera Limited (GB) | 2020-10-28 | — | — | EP | disclosed |
| CN-110167943-A | Pyrrolotriazine derivatives as kinase inhibitor | 株式会社大熊制药 | 2019-08-23 | — | — | CN | disclosed |
| CN-107108648-B | Thieno [2,3-c] pyrroles's -4- ketone derivatives as ERK inhibitor | 伊莱利利公司 | 2019-07-12 | — | — | CN | disclosed |
| US-9526733-B1 | ERK inhibitors | ELI LILLY AND COMPANY (US) | 2016-12-27 | — | — | US | disclosed |
| US-9526733-B1 | ERK inhibitors | ELI LILLY AND COMPANY (US) | 2016-12-27 | — | — | US | disclosed |
| US-9469652-B2 | ERK inhibitors | ELI LILLY AND COMPANY (US) | 2016-10-18 | — | — | US | disclosed |
| US-9469652-B2 | ERK inhibitors | ELI LILLY AND COMPANY (US) | 2016-10-18 | — | — | US | disclosed |
| US-20160176896-A1 | ERK INHIBITORS | ELI LILLY AND COMPANY | 2016-06-23 | — | — | US | disclosed |
| US-20160176896-A1 | ERK INHIBITORS | ELI LILLY AND COMPANY | 2016-06-23 | — | — | US | disclosed |
| EP-1994025-A1 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007099326-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | disclosed |
| EP-0789698-A1 | N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES | DOWELANCO (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1997008172-A1 | N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES | DOWELANCO (US) | 1997-03-06 | — | — | WO | disclosed |