Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 2/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200813 | 0.85 | NOTUM (0.51) | NOTUMHPGDCHRNB4CHRNA3OPRM1 | |
| SCHEMBL3227444 | 0.82 | NOTUM (0.49) | NOTUMHPGDCHRNB4CHRNA3OPRM1 | |
| SCHEMBL21142478 | 0.79 | NOTUM (0.46) | NOTUMHPGDCHRNB4CHRNA3OPRM1 | |
| SCHEMBL8669245 | 0.78 | HPGD (0.44) | NOTUMHPGDCHRNB4CHRNA3OPRM1 | |
| SCHEMBL5122585 | 0.78 | NOTUM (0.45) | NOTUMHPGDCHRNB4CHRNA3OPRM1 | |
| SCHEMBL4553514 | 0.78 | NOTUM (0.53) | NOTUMHPGDCHRNB4CHRNA3OPRM1 | |
| SCHEMBL22401875 | 0.77 | NOTUM (0.44) | NOTUMHPGDCHRNB4CHRNA3OPRM1 | |
| SCHEMBL5989585 | 0.73 | NOTUM (0.55) | NOTUMHPGDCHRNB4CHRNA3OPRM1 | |
| SCHEMBL7207045 | 0.73 | NOTUM (0.44) | NOTUMHPGDCHRNB4CHRNA3OPRM1 | |
| SCHEMBL5504251 | 0.73 | CASP3 (0.43) | NOTUMHPGDCHRNB4CHRNA3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210169892-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC | 2021-06-10 | — | — | US | disclosed |
| EP-1706113-B1 | A PROCESS FOR THE PREPARATION OF 4-(2-DIPROPYLAMINOETHYL)-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE | USV LTD (IN) | 2008-12-10 | — | — | EP | disclosed |
| US-7378439-B2 | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride | USV, LTD. (IN) | 2008-05-27 | — | — | US | disclosed |
| CN-1909901-A | A process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride | USV LTD (IN) | 2007-02-07 | — | — | CN | disclosed |
| EP-1706113-A1 | A PROCESS FOR THE PREPARATION OF 4-(2-DIPROPYLAMINOETHYL)-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE | USV Limited (IN) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005067922-A1 | A PROCESS FOR THE PREPARATION OF 4-(2-DIPROPYLAMINOETHYL)-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE | USV LIMITED (IN) | 2005-07-28 | — | — | WO | disclosed |
| US-20050159605-A1 | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride | USV LIMITED (IN) | 2005-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159605-A1 | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride | PARK7, SNCA, TPH1 | NOTUM 3620/4885HPGD 1152/4885CHRNB4 216/4885 |
| US-20210169892-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | NOTUM 4116/4885HPGD 861/4885CHRNB4 4097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.