SCHEMBL465719

SCHEMBL465719

COC(=O)c1cccc(CCl)n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 2/20 0.54
CYP1A2 P05177 3/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
TP53 P04637 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
MAPT P10636 4/20 0.50
PARP1 P09874 1/20 0.48
GAA P10253 1/20 0.48
RECQL P46063 1/20 0.48
ADORA2A P29274 1/20 0.44
GRM5 P41594 1/20 0.43
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43
TSHR P16473 1/20 0.43
HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29490154 1.00 MRGPRX4 (0.54) MRGPRX4CYP1A2SMN1; SMN2NPC1RAB9A
Hydrochloric Acid SCHEMBL21044004 0.98 MRGPRX4 (0.53) MRGPRX4CYP1A2SMN1; SMN2NPC1RAB9A
SCHEMBL183978 0.84 MRGPRX4 (0.52) MRGPRX4CYP1A2SMN1; SMN2NPC1RAB9A
SCHEMBL30022926 0.84 MRGPRX4 (0.52) MRGPRX4CYP1A2SMN1; SMN2NPC1RAB9A
SCHEMBL6117260 0.84 CYP1A2 (0.53) MRGPRX4CYP1A2SMN1; SMN2NPC1RAB9A
SCHEMBL7671391 0.84 MRGPRX4 (0.52) MRGPRX4CYP1A2SMN1; SMN2NPC1RAB9A
SCHEMBL1698714 0.83 CYP1A2 (0.72) MRGPRX4CYP1A2SMN1; SMN2NPC1RAB9A
SCHEMBL21199935 0.83 MRGPRX4 (0.51) MRGPRX4CYP1A2SMN1; SMN2NPC1RAB9A
SCHEMBL22451835 0.83 MRGPRX4 (0.51) MRGPRX4CYP1A2SMN1; SMN2NPC1RAB9A
SCHEMBL22002661 0.83 MRGPRX4 (0.58) MRGPRX4CYP1A2SMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 219 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108482-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS INC (US) 2026-04-23 US disclosed
US-12595249-B2 Aryl ether-substituted heterocyclic compounds as glpir agonists MINDRANK AI LTD. (CN) 2026-04-07 US disclosed
US-12497384-B2 Aryl ether-substituted heterocyclic compounds as GLP1R agonists MINDRANK AI LTD. (CN) 2025-12-16 US disclosed
WO-2025231152-A1 COMPOUNDS AND METHODS FOR RESTORING BETA-ADRENERGIC RECEPTOR FUNCTION THE CLEVELAND CLINIC FOUNDATION (US) 2025-11-06 WO disclosed
US-12453785-B2 Macrocyclic chelators and methods of use thereof JANSSEN BIOTECH, INC. (US) 2025-10-28 US disclosed
US-20250325718-A1 IMMUNOCONJUGATES COMPRISING KALLIKREIN RELATED PEPTIDASE 2 ANTIGEN BINDING DOMAINS AND THEIR USES JANSSEN BIOTECH INC (US) 2025-10-23 US disclosed
US-20250304553-A1 ARYL ETHER-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS GLP1R AGONISTS MINDRANK AI LTD. (CN) 2025-10-02 US disclosed
US-20250282757-A1 ARYL ETHER-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS GLP1R AGONISTS MINDRANK AI LTD. (CN) 2025-09-11 US disclosed
US-12378200-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ORSOBIO, INC. (US) 2025-08-05 US disclosed
US-20250214985-A1 MACROCYCLIC COMPLEXES OF ALPHA-EMITTING RADIONUCLIDES AND THEIR USE IN TARGETED RADIOTHERAPY OF CANCER CORNELL UNIVERSITY (US) 2025-07-03 US disclosed
EP-2129670-A2 BENZOFURAN COMPOUNDS USEFUL IN THE TREATMENT OF CONDITIONS MEDIATED BY THE ACTION OF PGE2 AT THE EP1 RECEPTOR Glaxo Group Limited (GB) 2009-12-09 EP disclosed
US-20090099169-A1 Benzofuran Compounds As EP1 Receptor Antagonists GLAXO GROUP LIMITED (GB) 2009-04-16 US disclosed
US-20090099169-A1 Benzofuran Compounds As EP1 Receptor Antagonists GLAXO GROUP LIMITED (GB) 2009-04-16 US disclosed
US-20090099169-A1 Benzofuran Compounds As EP1 Receptor Antagonists GLAXO GROUP LIMITED (GB) 2009-04-16 US disclosed
EP-2001872-A1 BENZOFURAN COMPOUNDS AS EP1 RECEPTOR ANTAGONISTS GLAXO GROUP LIMITED (GB) 2008-12-17 EP disclosed
WO-2008098978-A2 BENZOFURAN COMPOUNDS USEFUL IN THE TREATMENT OF CONDITIONS MEDIATED BY THE ACTION OF PGE2 AT THE EP1 RECEPTOR GLAXO GROUP LIMITED (GB) 2008-08-21 WO disclosed
WO-2008098978-A2 BENZOFURAN COMPOUNDS USEFUL IN THE TREATMENT OF CONDITIONS MEDIATED BY THE ACTION OF PGE2 AT THE EP1 RECEPTOR GLAXO GROUP LIMITED (GB) 2008-08-21 WO disclosed
WO-2007113289-A1 BENZOFURAN COMPOUNDS AS EP1 RECEPTOR ANTAGONISTS GLAXO GROUP LIMITED (GB) 2007-10-11 WO disclosed
WO-2007113289-A1 BENZOFURAN COMPOUNDS AS EP1 RECEPTOR ANTAGONISTS GLAXO GROUP LIMITED (GB) 2007-10-11 WO disclosed
US-5559134-A Leukotriene-B4 antagonists, process for their production and their use as pharmaceutical agents SCHERING AKTIENGESELLSCHAFT (DE) 1996-09-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12378200-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ALDH7A1, ACMSD, AMD1 MRGPRX4 2962/4885CYP1A2 1217/4885SMN1; SMN2 2338/4885
US-12497384-B2 Aryl ether-substituted heterocyclic compounds as GLP1R agonists GLP1R, GIPR, GCGR MRGPRX4 172/4885CYP1A2 1326/4885SMN1; SMN2 3544/4885
US-20090099169-A1 Benzofuran Compounds As EP1 Receptor Antagonists PTGER1, PTGER2, PTGER3 MRGPRX4 286/4885CYP1A2 208/4885SMN1; SMN2 2462/4885
US-12595249-B2 Aryl ether-substituted heterocyclic compounds as glpir agonists GLP1R, GIPR, GCGR MRGPRX4 302/4885CYP1A2 3054/4885SMN1; SMN2 2018/4885
US-20250304553-A1 ARYL ETHER-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS GLP1R AGONISTS GLP1R, GIPR, GCGR MRGPRX4 331/4885CYP1A2 1423/4885SMN1; SMN2 2170/4885
US-20260108482-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 MRGPRX4 1/4885CYP1A2 1885/4885SMN1; SMN2 4376/4885
US-20250282757-A1 ARYL ETHER-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS GLP1R AGONISTS GLP1R, GIPR, GCGR MRGPRX4 178/4885CYP1A2 1392/4885SMN1; SMN2 3746/4885
US-20250325718-A1 IMMUNOCONJUGATES COMPRISING KALLIKREIN RELATED PEPTIDASE 2 ANTIGEN BINDING DOMAINS AND THEIR USES KLK3, KLK2, KLKB1 MRGPRX4 1398/4885CYP1A2 4090/4885SMN1; SMN2 4198/4885
US-12453785-B2 Macrocyclic chelators and methods of use thereof CLASP1, CLTC, CD47 MRGPRX4 881/4885CYP1A2 4570/4885SMN1; SMN2 3975/4885
US-20250214985-A1 MACROCYCLIC COMPLEXES OF ALPHA-EMITTING RADIONUCLIDES AND THEIR USE IN TARGETED RADIOTHERAPY OF CANCER PSMA1, FOLH1, KLK3 MRGPRX4 445/4885CYP1A2 4705/4885SMN1; SMN2 1817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.