Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659048 | 0.98 | HRH3 (0.54) | HRH3MBTD1L3MBTL3L3MBTL1HRH4 | |
| SCHEMBL4659009 | 0.85 | HRH3 (0.53) | HRH3HRH4ALDH1A1KDM4E | |
| SCHEMBL4657919 | 0.85 | HRH3 (0.61) | HRH3ALDH1A1KDM4E | |
| SCHEMBL4659011 | 0.82 | HRH3 (0.55) | HRH3ALDH1A1KDM4E | |
| SCHEMBL4659051 | 0.81 | DRD4 (0.56) | ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL4659014 | 0.81 | HRH3 (0.54) | HRH3ALDH1A1KDM4E | |
| SCHEMBL4657761 | 0.80 | HRH3 (0.52) | HRH3NCF1ALDH1A1KDM4E | |
| SCHEMBL3762346 | 0.77 | HRH3 (0.50) | HRH3ALDH1A1KDM4E | |
| SCHEMBL4658971 | 0.76 | HRH3 (0.64) | HRH3 | |
| SCHEMBL4658026 | 0.76 | CCR3 (0.63) | HRH3L3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753757-B1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | GRUENENTHAL GMBH (DE) | 2008-12-10 | — | — | EP | disclosed |
| US-20070135403-A1 | Substituted 2,5-diaminomethyl-1H-pyrrole compounds | GRUENENTHAL GMBH (DE) | 2007-06-14 | — | — | US | disclosed |
| EP-1753757-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005113549-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135403-A1 | Substituted 2,5-diaminomethyl-1H-pyrrole compounds | OPRL1, OPRK1, OPRM1 | HRH3 567/4885MBTD1 3654/4885L3MBTL3 4537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.