Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.64 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | ACHE | P22303 | 6/20 | 0.46 |
| ▸ | BCHE | P06276 | 5/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4658921 | 0.83 | LSS (0.48) | HRH3SIGMAR1ACHE | |
| SCHEMBL4657913 | 0.83 | CCR3 (0.56) | SIGMAR1 | |
| SCHEMBL4659009 | 0.81 | HRH3 (0.53) | HRH3 | |
| SCHEMBL4657753 | 0.80 | ALDH1A1 (0.48) | HRH3 | |
| SCHEMBL4659048 | 0.78 | HRH3 (0.54) | HRH3 | |
| SCHEMBL4657901 | 0.76 | HRH3 (0.50) | HRH3 | |
| SCHEMBL792219 | 0.76 | SIGMAR1 (0.71) | HRH3SIGMAR1 | |
| SCHEMBL4658026 | 0.75 | CCR3 (0.63) | HRH3SIGMAR1 | |
| SCHEMBL4659011 | 0.75 | HRH3 (0.55) | HRH3 | |
| Hydrochloric Acid SCHEMBL8694185 | 0.75 | SIGMAR1 (0.69) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753757-B1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | GRUENENTHAL GMBH (DE) | 2008-12-10 | — | — | EP | claimed |
| US-20070135403-A1 | Substituted 2,5-diaminomethyl-1H-pyrrole compounds | GRUENENTHAL GMBH (DE) | 2007-06-14 | — | — | US | claimed |
| EP-1753757-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2007-02-21 | — | — | EP | claimed |
| WO-2005113549-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | claimed |
| EP-1753757-B1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | GRUENENTHAL GMBH (DE) | 2008-12-10 | — | — | EP | disclosed |
| US-20070135403-A1 | Substituted 2,5-diaminomethyl-1H-pyrrole compounds | GRUENENTHAL GMBH (DE) | 2007-06-14 | — | — | US | disclosed |
| EP-1753757-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005113549-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135403-A1 | Substituted 2,5-diaminomethyl-1H-pyrrole compounds | OPRL1, OPRK1, OPRM1 | HRH3 567/4885CXCR4 1008/4885SIGMAR1 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.