Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | JUN | P05412 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450487 | 0.80 | CYP11B1 (0.59) | CYP11B1CYP11B2ALOX5CHRNB2CHRNA4 | |
| SCHEMBL9967696 | 0.80 | CYP11B1 (0.59) | CYP11B1CYP11B2ALOX5CHRNB2CHRNA4 | |
| SCHEMBL3012379 | 0.79 | CYP11B1 (0.53) | CYP11B1CYP11B2ALOX5CHRNB2CHRNA4 | |
| SCHEMBL3012381 | 0.79 | CYP11B1 (0.53) | CYP11B1CYP11B2ALOX5CHRNB2CHRNA4 | |
| SCHEMBL10193817 | 0.77 | ALOX5 (0.55) | CYP11B1CYP11B2ALOX5CHRNB2CHRNA4 | |
| SCHEMBL3013280 | 0.77 | CHRNB2 (0.59) | CYP11B1CYP11B2ALOX5CHRNB2CHRNA4 | |
| SCHEMBL3013279 | 0.77 | CHRNB2 (0.59) | CYP11B1CYP11B2ALOX5CHRNB2CHRNA4 | |
| SCHEMBL6450540 | 0.75 | CHRNB2 (0.53) | CYP11B1CYP11B2ALOX5CHRNB2CHRNA4 | |
| SCHEMBL3017118 | 0.73 | CHRNB2 (0.51) | CYP11B1CYP11B2ALOX5CHRNB2CHRNA4 | |
| SCHEMBL3017116 | 0.73 | CHRNB2 (0.51) | CYP11B1CYP11B2ALOX5CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900200-B1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | TARGACEPT INC (US) | 2008-12-03 | — | — | EP | claimed |