Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3204087 | 0.84 | SERPINE1 (0.54) | FPR2SMN1; SMN2MAPTSERPINE1POLB | |
| SCHEMBL4659034 | 0.83 | FPR2 (0.52) | FPR2CTSSHPGDPPARA | |
| SCHEMBL27718131 | 0.77 | FPR2 (0.41) | FPR2SMN1; SMN2MAPTSERPINE1PLA2G1B | |
| SCHEMBL27718130 | 0.77 | FPR2 (0.41) | FPR2SMN1; SMN2MAPTSERPINE1PLA2G1B | |
| SCHEMBL3200336 | 0.77 | SERPINE1 (0.51) | FPR2SMN1; SMN2MAPTSERPINE1 | |
| SCHEMBL13319075 | 0.70 | BRPF1 (0.43) | SMN1; SMN2MAPTHPGDPLA2G4ATP53 | |
| SCHEMBL28771761 | 0.68 | HSD17B10 (0.50) | SMN1; SMN2MAPTPOLBKMT2AALDH1A1 | |
| SCHEMBL3206680 | 0.68 | NTSR1 (0.53) | FPR2SERPINE1 | |
| SCHEMBL13319074 | 0.66 | NR3C2 (0.41) | SMN1; SMN2MAPTHPGDPLA2G4AKMT2A | |
| SCHEMBL8239652 | 0.63 | NTSR1 (0.41) | MAPTPOLBKMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919866-A2 | SUBSTITUTED INDOLES AND USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-05-14 | — | — | EP | claimed |
| WO-2007022321-A2 | SUBSTITUTED INDOLES AND USE THEREOF | WYETH (US) | 2007-02-22 | — | — | WO | claimed |
| EP-1919866-A2 | SUBSTITUTED INDOLES AND USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007022321-A2 | SUBSTITUTED INDOLES AND USE THEREOF | WYETH (US) | 2007-02-22 | — | — | WO | disclosed |