Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTSR1 | P30989 | 8/20 | 0.53 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.52 |
| ▸ | FPR2 | P25090 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3194968 | 0.88 | NTSR1 (0.60) | NTSR1SERPINE1 | |
| SCHEMBL3202701 | 0.88 | NTSR1 (0.64) | NTSR1 | |
| SCHEMBL3185435 | 0.88 | SERPINE1 (0.52) | SERPINE1FPR2 | |
| SCHEMBL3193084 | 0.86 | NTSR1 (0.59) | NTSR1SERPINE1HTR6 | |
| SCHEMBL3328211 | 0.86 | NTSR1 (0.59) | NTSR1SERPINE1HTR6 | |
| SCHEMBL4659034 | 0.85 | FPR2 (0.52) | NTSR1FPR2 | |
| SCHEMBL3204087 | 0.83 | SERPINE1 (0.54) | SERPINE1FPR2 | |
| SCHEMBL3200336 | 0.78 | SERPINE1 (0.51) | SERPINE1FPR2 | |
| SCHEMBL3201141 | 0.77 | NTSR1 (0.75) | NTSR1 | |
| SCHEMBL3196667 | 0.76 | NTSR1 (0.79) | NTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137363-A1 | Substituted Indoles And Methods Of Their Use | WYETH LLC (US) | 2010-06-03 | — | — | US | claimed |
| EP-1919866-A2 | SUBSTITUTED INDOLES AND USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-05-14 | — | — | EP | claimed |
| WO-2007022321-A2 | SUBSTITUTED INDOLES AND USE THEREOF | WYETH (US) | 2007-02-22 | — | — | WO | claimed |
| US-20100137363-A1 | Substituted Indoles And Methods Of Their Use | WYETH LLC (US) | 2010-06-03 | — | — | US | disclosed |
| US-7683091-B2 | Substituted indoles and methods of their use | WYETH (US) | 2010-03-23 | — | — | US | disclosed |
| EP-1919866-A2 | SUBSTITUTED INDOLES AND USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-05-14 | — | — | EP | disclosed |
| US-20070043101-A1 | Substituted indoles and methods of their use | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
| WO-2007022321-A2 | SUBSTITUTED INDOLES AND USE THEREOF | WYETH (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043101-A1 | Substituted indoles and methods of their use | INMT, AANAT, IDO2 | NTSR1 411/4885SERPINE1 4756/4885FPR2 1575/4885 |
| US-20100137363-A1 | Substituted Indoles And Methods Of Their Use | INMT, AANAT, IDO2 | NTSR1 411/4885SERPINE1 4756/4885FPR2 1575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.