Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.64 |
| ▸ | SLC6A9 | P48067 | 11/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433161 | 0.93 | SLC6A4 (0.69) | SLC6A4HRH3SLC6A9HTR1AKDM4E | |
| Oxalic Acid SCHEMBL7317614 | 0.85 | SLC6A4 (0.88) | SLC6A4HRH3SLC6A9KDM4EMEN1 | |
| Oxalic Acid SCHEMBL3980 | 0.85 | SLC6A4 (0.64) | SLC6A4HRH3SLC6A9HTR1AKDM4E | |
| Oxalic Acid SCHEMBL4740319 | 0.83 | SLC6A4 (0.72) | SLC6A4HRH3SLC6A9UTS2RCYP2D6 | |
| Oxalic Acid SCHEMBL10359897 | 0.81 | SLC6A4 (0.62) | SLC6A4HRH3SLC6A9UTS2R | |
| SCHEMBL679320 | 0.79 | SLC6A4 (1.00) | SLC6A4HRH3SLC6A9KDM4EMEN1 | |
| SCHEMBL29700710 | 0.79 | SLC6A4 (1.00) | SLC6A4HRH3SLC6A9KDM4EMEN1 | |
| SCHEMBL4660 | 0.77 | HTR1A (0.46) | SLC6A4HRH3SLC6A9HTR1AKDM4E | |
| Oxalic Acid SCHEMBL3801 | 0.77 | SLC6A4 (0.62) | SLC6A4HRH3SLC6A9UTS2R | |
| SCHEMBL13780465 | 0.76 | SLC6A9 (0.77) | SLC6A4HRH3SLC6A9KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |