Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30094656 | 0.89 | ALOX5AP (0.43) | ALDH1A1L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL11869553 | 0.89 | ALOX5AP (0.43) | ALDH1A1L3MBTL1MAPTMEN1KMT2A | |
| 1,2-Diethoxybenzene SCHEMBL28293847 | 0.85 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1MAPTNPSR1GLA | |
| SCHEMBL1553402 | 0.83 | CA1 (0.54) | ALDH1A1L3MBTL1MAPTCYP1A2TDP1 | |
| 1,2-Diethoxybenzene SCHEMBL578986 | 0.82 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1MAPTNPSR1GLA | |
| 1,2-Diethoxybenzene SCHEMBL29428929 | 0.82 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1MAPTNPSR1GLA | |
| SCHEMBL10192222 | 0.80 | L3MBTL1 (0.55) | L3MBTL1MAPTNPSR1MEN1KMT2A | |
| 1,2-Diethoxybenzene SCHEMBL8912901 | 0.80 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1MAPTNPSR1GLA | |
| SCHEMBL31186856 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPTNPSR1GLACYP1A2 | |
| SCHEMBL10467741 | 0.79 | L3MBTL1 (0.53) | ALDH1A1L3MBTL1MAPTNPSR1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100579958-C | Racemized tamsulosin free alkali and preparation method thereof | SYNTHON BV | 2010-01-13 | — | — | CN | disclosed |
| EP-1444199-B1 | RACEMIC TAMSULOSIN FREE BASE AND METHODS OF MAKING THE SAME | SYNTHON BV (NL) | 2008-12-17 | — | — | EP | disclosed |
| EP-1905758-A1 | Tamsulosin free base and recovery process thereof | Synthon B.V. (NL) | 2008-04-02 | — | — | EP | disclosed |
| CN-100343227-C | Process for resolution of tamsulosin | SYNTHON BV (NL) | 2007-10-17 | — | — | CN | disclosed |
| US-6965051-B2 | Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith | SYNTHON IP INC. (US) | 2005-11-15 | — | — | US | disclosed |
| US-20050096394-A1 | Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith | HOORN HANS J (NL) | 2005-05-05 | — | — | US | disclosed |
| CN-1578761-A | Process for resolution of tamsulosin | SYNTHON BV (NL) | 2005-02-09 | — | — | CN | disclosed |
| CN-1578762-A | Racemic tamsulosin free base and process for preparing same | SYNTHON BV (NL) | 2005-02-09 | — | — | CN | disclosed |
| US-6835853-B2 | Purification of racemic mixtures | SYNTHON BV (NL) | 2004-12-28 | — | — | US | disclosed |
| EP-1444199-A1 | RACEMIC TAMSULOSIN FREE BASE AND METHODS OF MAKING THE SAME | Synthon B.V. (NL) | 2004-08-11 | — | — | EP | disclosed |
| EP-1444198-A1 | PROCESS FOR RESOLUTION OF TAMSULOSIN | Synthon B.V. (NL) | 2004-08-11 | — | — | EP | disclosed |
| US-20030109752-A1 | Process for resolution of tamsulosin and compounds, compositons, and processes associated therewith | SYNTHON IP INC. | 2003-06-12 | — | — | US | disclosed |
| WO-2003037851-A1 | RACEMIC TAMSULOSIN FREE BASE AND METHODS OF MAKING THE SAME | SYNTHON B.V. (NL) | 2003-05-08 | — | — | WO | disclosed |
| WO-2003037850-A1 | PROCESS FOR RESOLUTION OF TAMSULOSIN | SYNTHON B.V. (NL) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096394-A1 | Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith | REN, ADRB1, ARRB1 | ALDH1A1 1718/4885L3MBTL1 4620/4885MAPT 2978/4885 |
| US-20030109752-A1 | Process for resolution of tamsulosin and compounds, compositons, and processes associated therewith | NPSR1, REN, PTMA | ALDH1A1 2749/4885L3MBTL1 4197/4885MAPT 1943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.