Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659435 | 0.78 | IDO1 (0.43) | RIPK1 | |
| SCHEMBL4659409 | 0.78 | MAPK8 (0.40) | RIPK1CES2CES1TRPA1 | |
| SCHEMBL29517836 | 0.77 | RIPK1 (0.50) | RIPK1CES2CES1NTRK1CHRM4 | |
| SCHEMBL15271780 | 0.77 | RIPK1 (0.50) | RIPK1CES2CES1NTRK1CHRM4 | |
| SCHEMBL1294867 | 0.75 | AOC2 (0.40) | RIPK1CES2CES1 | |
| SCHEMBL1294869 | 0.75 | AOC2 (0.40) | RIPK1CES2CES1 | |
| SCHEMBL1295619 | 0.75 | AOC2 (0.40) | RIPK1CES2CES1 | |
| SCHEMBL4660728 | 0.75 | TRPA1 (0.39) | RIPK1CES2CES1TRPA1 | |
| SCHEMBL6858266 | 0.72 | RIPK1 (0.49) | RIPK1CES2CES1NTRK1 | |
| SCHEMBL12108023 | 0.71 | RIPK1 (0.39) | RIPK1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004166-A2 | INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES | LA JOLLA PHARMACEUTICAL COMPANY (US) | 2008-12-24 | — | — | EP | claimed |
| WO-2007120528-A2 | INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES | LA JOLLA PHARMACEUTICAL COMPANY (US) | 2007-10-25 | — | — | WO | claimed |