Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4660728 | 0.81 | TRPA1 (0.39) | — | |
| SCHEMBL1294669 | 0.78 | MAOB (0.38) | DBHTUBB1HTR2AHTR2CHTR2B | |
| SCHEMBL1294728 | 0.78 | MAOB (0.38) | DBHTUBB1HTR2AHTR2CHTR2B | |
| SCHEMBL1294674 | 0.78 | MAOB (0.38) | DBHTUBB1HTR2AHTR2CHTR2B | |
| SCHEMBL7153647 | 0.78 | CYP3A4 (0.43) | DBHTUBB1ACACBCACNA1HCACNA1G | |
| SCHEMBL28151235 | 0.76 | TUBB1 (0.41) | DBHTUBB1ACACBCACNA1HCACNA1G | |
| SCHEMBL4659392 | 0.74 | MAOA (0.44) | — | |
| SCHEMBL2126253 | 0.74 | THRB (0.46) | DBHTUBB1 | |
| SCHEMBL14939021 | 0.73 | TUBB1 (0.39) | DBHTUBB1ACACB | |
| SCHEMBL2126802 | 0.73 | HSP90AB1 (0.56) | DBHTUBB1ACACBCACNA1HCACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004166-A2 | INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES | LA JOLLA PHARMACEUTICAL COMPANY (US) | 2008-12-24 | — | — | EP | claimed |
| WO-2007120528-A2 | INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES | LA JOLLA PHARMACEUTICAL COMPANY (US) | 2007-10-25 | — | — | WO | claimed |