Sugi Predict

Sugi Predict / Compounds / SCHEMBL4661745

SCHEMBL4661745

SCHEMBL4661745

CCOC(=O)CC(=Cc1ccccc1)C(=O)OCC

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 5/20 0.68
▸ KMT2A Q03164 5/20 0.68
▸ NR1H4 Q96RI1 1/20 0.51
▸ MAPT P10636 6/20 0.50
▸ LMNA P02545 4/20 0.50
▸ NPSR1 Q6W5P4 2/20 0.50
▸ CYP1A2 P05177 1/20 0.50
▸ CYP2C9 P11712 1/20 0.50
▸ CYP2C19 P33261 1/20 0.50
▸ S1PR4 O95977 1/20 0.50
▸ S1PR1 P21453 1/20 0.50
▸ MAPK1 P28482 1/20 0.50
▸ RECQL P46063 1/20 0.50
▸ ALDH1A1 P00352 6/20 0.48
▸ POLB P06746 2/20 0.48
▸ NPC1 O15118 1/20 0.48
▸ RAB9A P51151 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ NR1I2 O75469 1/20 0.47
▸ GAA P10253 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4661744 1.00 MEN1 (0.68) MEN1KMT2ANR1H4MAPTLMNA
SCHEMBL7300691 0.90 MEN1 (0.68) MEN1KMT2ANR1H4MAPTLMNA
SCHEMBL7300688 0.90 MEN1 (0.68) MEN1KMT2ANR1H4MAPTLMNA
SCHEMBL14198607 0.87 MEN1 (0.72) MEN1KMT2ANR1H4MAPTLMNA
SCHEMBL13103426 0.87 MEN1 (0.72) MEN1KMT2ANR1H4MAPTLMNA
Malonic Acid Diethyl Ester SCHEMBL8368278 0.85 MEN1 (0.87) MEN1KMT2ANR1H4MAPTLMNA
SCHEMBL3331849 0.85 KMT2A (0.49) MEN1KMT2AMAPTLMNANPSR1
SCHEMBL5963732 0.84 MEN1 (0.68) MEN1KMT2ANR1H4MAPTLMNA
SCHEMBL5963731 0.84 MEN1 (0.68) MEN1KMT2ANR1H4MAPTLMNA
SCHEMBL18961296 0.83 KMT2A (0.50) MEN1KMT2AMAPTLMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1392638-B1 PROCESS FOR PREPARING ALKYLIDENE SUBSTITUTED SUCCINIC ACID ESTERS BASELL POLIOLEFINE ITALIA SRL (IT) 2016-12-14 — — EP disclosed
EP-1527039-B1 PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES BASELL POLIOLEFINE SRL (IT) 2008-12-24 — — EP disclosed
US-7465821-B2 Process for preparing alkylidene-substituted-1, 4-dions derivatives BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2008-12-16 — — US disclosed
US-7399879-B2 Process for preparing alkylidene-substituted-1,4-dions derivatives BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2008-07-15 — — US disclosed
CN-100349850-C Process for preparing alkylene substituted succinic acid esters BASELL POLIOLEFINE SPA (IT) 2007-11-21 — — CN disclosed
US-6914153-B2 Process for preparing alkylidene substituted succinic acid esters BASSELL POLIOLEFINE ITALIA S.P.A. (IT) 2005-07-05 — — US disclosed
US-20050113599-A1 Process for preparing alkylidene-substituted -1, 4-dions derivatives BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2005-05-26 — — US disclosed
EP-1527040-A1 PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES Basel Poliolefine Italia SpA (IT) 2005-05-04 — — EP disclosed
EP-1527039-A1 PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES Basell Poliolefine Italia S.P.A. (IT) 2005-05-04 — — EP disclosed
US-20050080290-A1 Process for preparing alkylidene-substituted-1, 4-dions derivatives BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2005-04-14 — — US disclosed
CN-1512979-A Process for preparing alkylidene substituted succinic acid esters ��������ϩ����������޹�˾ 2004-07-14 — — CN disclosed
EP-1392638-A1 PROCESS FOR PREPARING ALKYLIDENE SUBSTITUTED SUCCINIC ACID ESTERS Basell Poliolefine Italia S.p.A. (IT) 2004-03-03 — — EP disclosed
WO-2004014838-A1 PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2004-02-19 — — WO disclosed
WO-2004014839-A1 PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES BASEL POLIOLEFINE ITALIA S.P.A. (IT) 2004-02-19 — — WO disclosed
US-20030181743-A1 Process for preparing alkylidene substituted succinic acid esters BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2003-09-25 — — US disclosed
WO-2002098837-A1 PROCESS FOR PREPARING ALKYLIDENE SUBSTITUTED SUCCINIC ACID ESTERS BASELL POLIOLEFINE ITALIA S.P.A (IT) 2002-12-12 — — WO disclosed
EP-0248631-B1 PHOTOCHROMIC GAMMA BUTYROLACTONES GEC-MARCONI LIMITED (GB) 1991-05-02 — — EP disclosed
US-4942113-A Contrast enhanced photolithography PLESSEY OVERSEAS LIMITED (GB) 1990-07-17 — — US disclosed
US-4861899-A Photochromic gamma butyrolactones THE PLESSEY COMPANY PLC. (GB) 1989-08-29 — — US disclosed
EP-0239376-A2 Contrast enhanced photolithography GEC-MARCONI LIMITED (GB) 1987-09-30 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050113599-A1 Process for preparing alkylidene-substituted -1, 4-dions derivatives KCNJ4, NR3C2, NR4A2 MEN1 793/4885KMT2A 626/4885NR1H4 49/4885
US-20030181743-A1 Process for preparing alkylidene substituted succinic acid esters OGDH, SCO2, SUCNR1 MEN1 1685/4885KMT2A 980/4885NR1H4 1466/4885
US-20050080290-A1 Process for preparing alkylidene-substituted-1, 4-dions derivatives RTN4, NR4A2, NR3C2 MEN1 1855/4885KMT2A 2796/4885NR1H4 30/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.