Sugi Predict

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SCHEMBL4663130

SCHEMBL4663130

Cc1cccc(C(=O)NC(C)C)c1NC(=O)c1cnc(C(F)(F)F)nc1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 4/20 0.46
▸ PDE4A P27815 2/20 0.39
▸ PDE4C Q08493 2/20 0.39
▸ PDE4D Q08499 2/20 0.39
▸ PDE3B Q13370 2/20 0.39
▸ PDE11A Q9HCR9 2/20 0.39
▸ RXFP1 Q9HBX9 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ XPO1 O14980 1/20 0.39
▸ JUN P05412 1/20 0.39
▸ NFKB1 P19838 1/20 0.39
▸ NFKB2 Q00653 1/20 0.39
▸ RELA Q04206 1/20 0.39
▸ MAPT P10636 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ JAK2 O60674 1/20 0.37
▸ JAK1 P23458 1/20 0.37
▸ JAK3 P52333 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1382114 0.83 LMNA (0.54) PDE4BPDE4APDE4CPDE4DNPSR1
SCHEMBL4662798 0.77 NPSR1 (0.52) RXFP1POLBALDH1A1KDM4ENPSR1
SCHEMBL1381716 0.76 KDM4E (0.54) RXFP1MAPTKDM4ENPSR1P2RX1
SCHEMBL14263664 0.72 SMN1; SMN2 (0.46) POLBALDH1A1KDM4ECASP3
SCHEMBL4664426 0.71 KDM4E (0.51) KDM4E
SCHEMBL4666449 0.70 AURKA (0.48) ALDH1A1NPSR1CYP3A4P2RX1
SCHEMBL3278308 0.69 KLKB1 (0.50) MAPT
SCHEMBL5211177 0.68 POLB (0.42) POLBALDH1A1KDM4ECYP3A4CASP3
SCHEMBL24747289 0.67 RXFP1 (0.72) RXFP1POLBMAPTL3MBTL1
SCHEMBL30052889 0.67 RXFP1 (0.72) RXFP1POLBMAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1700845-B1 Insecticidal anthranilamides DU PONT (US) 2008-12-10 — — EP disclosed
EP-1265850-B1 INSECTICIDAL ANTHRANILAMIDES DU PONT (US) 2007-01-03 — — EP disclosed
EP-1700845-A1 Insecticidal anthranilamides E.I.Du pont de nemours and company (US) 2006-09-13 — — EP disclosed
US-20060079561-A1 Insecticidal anthranilamides FMC CORPORATION 2006-04-13 — — US disclosed
US-6995178-B2 Insecticidal anthranilamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2006-02-07 — — US disclosed
US-20040142984-A1 Insecticidal anthranilamides FMC CORPORATION 2004-07-22 — — US disclosed
US-6747047-B2 ARTHROPODICIDES E.I. DU PONT DE NEMOURS AND COMPANY 2004-06-08 — — US disclosed
US-20030229050-A1 Insecticidal anthranilamides FMC CORPORATION 2003-12-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142984-A1 Insecticidal anthranilamides ANTXR2, NIT2, AKR7A2 PDE4B 929/4885PDE4A 1098/4885PDE4C 1247/4885
US-20060079561-A1 Insecticidal anthranilamides ANTXR2, CYB5R3, NIT2 PDE4B 866/4885PDE4A 923/4885PDE4C 993/4885
US-20030229050-A1 Insecticidal anthranilamides ANTXR2, NIT2, CYB5R3 PDE4B 825/4885PDE4A 1030/4885PDE4C 1208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.