Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 10/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429410 | 1.00 | OPRK1 (0.58) | OPRK1OPRD1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL29565390 | 1.00 | OPRK1 (0.58) | OPRK1OPRD1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL145552 | 1.00 | OPRK1 (0.58) | OPRK1OPRD1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL29966565 | 1.00 | OPRK1 (0.58) | OPRK1OPRD1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL4665471 | 0.92 | OPRK1 (0.61) | OPRK1OPRD1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL147934 | 0.91 | OPRK1 (0.58) | OPRK1OPRD1SLC6A2SLC6A4OPRM1 | |
| Hydrochloric Acid SCHEMBL8617636 | 0.91 | OPRK1 (0.60) | OPRK1OPRD1SLC6A2SLC6A4OPRM1 | |
| Hydrochloric Acid SCHEMBL8615882 | 0.91 | OPRK1 (0.60) | OPRK1OPRD1SLC6A2SLC6A4OPRM1 | |
| Hydrochloric Acid SCHEMBL8613685 | 0.91 | OPRK1 (0.60) | OPRK1OPRD1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL4663621 | 0.91 | OPRM1 (0.49) | OPRK1OPRD1SLC6A2SLC6A4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1571140-B1 | C-substituted cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2008-11-12 | — | — | EP | claimed |
| US-7273952-B2 | Substituted C-cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2007-09-25 | — | — | US | claimed |
| US-20030232891-A1 | Substituted C-cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2003-12-18 | — | — | US | claimed |
| EP-1368299-A2 | SUBSTITUTED C-CYCLOHEXYLMETHYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2003-12-10 | — | — | EP | claimed |
| WO-2002030870-A2 | SUBSTITUTED C-CYCLOHEXYLMETHYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-18 | — | — | WO | claimed |
| CN-116367864-A | Controlled release filler composition and capsule containing the same | R·P·谢勒技术有限公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-116322655-A | Soft gel capsule for regulating release | R·P·谢勒技术有限公司 | 2023-06-23 | — | — | CN | disclosed |
| EP-2780000-A1 | TAMPER-RESISTANT ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING A PHARMACOLOGICALLY ACTIVE INGREDIENT, AN OPIOID ANTAGONIST AND/OR AVERSIVE AGENT, POLYALKYLENE OXIDE AND ANIONIC POLYMER | Grünenthal GmbH (DE) | 2014-09-24 | — | — | EP | disclosed |
| EP-2763664-A2 | TAMPER-RESISTANT ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING OPIOID AGONIST AND OPIOID ANTAGONIST | Grünenthal GmbH (DE) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013072395-A1 | TAMPER-RESISTANT ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING A PHARMACOLOGICALLY ACTIVE INGREDIENT, AN OPIOID ANTAGONIST AND/OR AVERSIVE AGENT, POLYALKYLENE OXIDE AND ANIONIC POLYMER | Grünenthal GmbH (DE) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013050539-A2 | TAMPER-RESISTANT ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING OPIOID AGONIST AND OPIOID ANTAGONIST | Grünenthal GmbH (DE) | 2013-04-11 | — | — | WO | disclosed |
| EP-1571140-B1 | C-substituted cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2008-11-12 | — | — | EP | disclosed |
| EP-1858496-A1 | TRANSDERMAL THERAPEUTIC SYSTEM FOR THE ADMINISTRATION OF ANALGESICS | GRUENENTHAL GMBH (DE) | 2007-11-28 | — | — | EP | disclosed |
| US-7273952-B2 | Substituted C-cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2007-09-25 | — | — | US | disclosed |
| WO-2006094961-A1 | TRANSDERMAL THERAPEUTIC SYSTEM FOR THE ADMINISTRATION OF ANALGESICS | GRUENENTHAL GMBH (DE) | 2006-09-14 | — | — | WO | disclosed |
| EP-1571140-A1 | C-substituted cyclohexylmethylamine derivatives | Grünenthal GmbH (DE) | 2005-09-07 | — | — | EP | disclosed |
| US-20030232891-A1 | Substituted C-cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2003-12-18 | — | — | US | disclosed |
| EP-1368299-A2 | SUBSTITUTED C-CYCLOHEXYLMETHYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002030870-A2 | SUBSTITUTED C-CYCLOHEXYLMETHYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232891-A1 | Substituted C-cyclohexylmethylamine derivatives | CNR2, CNR1, HNMT | OPRK1 6/4885OPRD1 25/4885SLC6A2 611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.