Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | VDR | P11473 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184532 | 0.88 | DHFR (0.41) | BACE1DHFRMAPTGPR84TRPA1 | |
| SCHEMBL22490117 | 0.84 | EGFR (0.46) | EGFRBACE1PKMDHFRVDR | |
| SCHEMBL606251 | 0.84 | TRPA1 (0.46) | EGFRBACE1PKMDHFRMAPT | |
| SCHEMBL22498582 | 0.82 | EGFR (0.34) | EGFRBACE1PKMDHFRVDR | |
| SCHEMBL22498510 | 0.82 | EGFR (0.34) | EGFRBACE1PKMDHFRVDR | |
| SCHEMBL7778148 | 0.79 | VDR (0.43) | EGFRVDRKDM4EALDH1A1 | |
| SCHEMBL19248505 | 0.79 | MAPT (0.37) | EGFRVDRMAPTKDM4EALDH1A1 | |
| SCHEMBL4706066 | 0.78 | BACE1 (0.59) | BACE1MAPTACE2KDM4ETRPA1 | |
| SCHEMBL11010604 | 0.78 | CNR1 (0.47) | BACE1VDRGPR84 | |
| SCHEMBL13586648 | 0.78 | TRPA1 (0.47) | BACE1MAPTKDM4ETRPA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139282-A2 | METHODS FOR THE PREPARATION OF SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS AND SOLID FORMS THEREOF | Cipla Limited (IN) | 2023-03-01 | — | — | EP | disclosed |
| EP-3947348-A1 | PROCESS FOR MAKING SIPONIMOD AND INTERMEDIATE THEREOF | Synthon B.V. (NL) | 2022-02-09 | — | — | EP | disclosed |
| WO-2021240547-A2 | METHODS FOR THE PREPARATION OF SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS AND SOLID FORMS THEREOF | CIPLA LIMITED (IN) | 2021-12-02 | — | — | WO | disclosed |
| WO-2020201172-A1 | PROCESS FOR MAKING SIPONIMOD AND INTERMEDIATE THEREOF | SYNTHON B.V. (NL) | 2020-10-08 | — | — | WO | disclosed |
| WO-2019064184-A1 | PROCESS FOR PREPARATION OF SIPONIMOD, ITS SALTS AND SOLID STATE FORMS THEREOF | DR. REDDY'S LABORATORIES LIMITED (IN) | 2019-04-04 | — | — | WO | disclosed |
| EP-1633336-A4 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2008-10-29 | — | — | EP | disclosed |
| EP-1633336-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004103306-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2004-12-02 | — | — | WO | disclosed |