Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 3/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.34 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL770110 | 0.76 | DHODH (0.41) | ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4663041 | 0.73 | S1PR1 (0.41) | RORCALDH1A1KDM4EAKR1C3AKR1C2 | |
| SCHEMBL27724772 | 0.73 | PDK2 (0.51) | SRD5A2ALDH1A1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL11855841 | 0.73 | ALDH1A1 (0.41) | ALDH1A1HPGDMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL28961906 | 0.71 | ALDH1A1 (0.41) | ALDH1A1HPGDMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL34475112 | 0.71 | HTR7 (0.41) | ALDH1A1KDM4ECYP1A2CYP2C9HPGD | |
| SCHEMBL3440706 | 0.71 | HTR7 (0.41) | ALDH1A1KDM4ECYP1A2CYP2C9HPGD | |
| SCHEMBL4663035 | 0.70 | S1PR1 (0.41) | RORCAKR1C3AKR1C2S1PR1S1PR3 | |
| SCHEMBL12598452 | 0.69 | AR (0.53) | — | |
| SCHEMBL4637120 | 0.68 | AKR1C3 (0.51) | RORCAKR1C3AKR1C2S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638551-B1 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2011-12-21 | — | — | EP | disclosed |
| EP-1638551-A4 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2008-12-31 | — | — | EP | disclosed |
| US-7060697-B2 | Immunosuppressant compounds and compositions | IRM LLC (BM) | 2006-06-13 | — | — | US | disclosed |
| EP-1638551-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2006-03-29 | — | — | EP | disclosed |
| US-20050014724-A1 | Immunosuppressant compounds and compositions | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2005-01-20 | — | — | US | disclosed |
| WO-2004103309-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2004-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014724-A1 | Immunosuppressant compounds and compositions | ICOS, EDNRA, NFATC1 | RORC 87/4885SRD5A2 689/4885ALDH1A1 3602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.