Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.38 |
| ▸ | STK10 | O94804 | 2/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4663035 | 0.83 | S1PR1 (0.41) | S1PR1S1PR3AKR1C3AKR1C2RORC | |
| SCHEMBL19086307 | 0.77 | PTGS2 (0.41) | AKR1C3AKR1C2PTGS2ESR2 | |
| SCHEMBL4637120 | 0.77 | AKR1C3 (0.51) | S1PR1S1PR3AKR1C3AKR1C2RORC | |
| SCHEMBL27638533 | 0.76 | S1PR1 (0.52) | S1PR1S1PR3L3MBTL1AKR1C3AKR1C2 | |
| SCHEMBL4781603 | 0.74 | KIF11 (0.54) | S1PR1S1PR3ALDH1A1 | |
| SCHEMBL3578278 | 0.74 | AR (0.40) | — | |
| SCHEMBL4664565 | 0.73 | RORC (0.38) | S1PR1S1PR3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL30608015 | 0.73 | KDM4E (0.44) | KDM4EAKR1C3AKR1C2STK10SLK | |
| SCHEMBL2942635 | 0.73 | S1PR1 (0.47) | S1PR1S1PR3ALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL19259678 | 0.73 | PTGS2 (0.41) | AKR1C3AKR1C2PTGS2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638551-A4 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2008-12-31 | — | — | EP | disclosed |
| EP-1638551-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004103309-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2004-12-02 | — | — | WO | disclosed |