Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 8/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4663041 | 0.83 | S1PR1 (0.41) | S1PR1S1PR3AKR1C3AKR1C2RORC | |
| SCHEMBL27638533 | 0.76 | S1PR1 (0.52) | S1PR1S1PR3GLAPOLBGAA | |
| SCHEMBL4781603 | 0.74 | KIF11 (0.54) | S1PR1S1PR3TSHRKIF11SCN9A | |
| SCHEMBL4662864 | 0.73 | KIF11 (0.44) | S1PR1AKR1C3AKR1C2RORCKIF11 | |
| SCHEMBL2942635 | 0.73 | S1PR1 (0.47) | S1PR1S1PR3GLAPOLBGAA | |
| SCHEMBL4637120 | 0.73 | AKR1C3 (0.51) | S1PR1S1PR3AKR1C3AKR1C2RORC | |
| SCHEMBL4664391 | 0.73 | S1PR1 (0.43) | S1PR1S1PR3GLAPOLBGAA | |
| SCHEMBL28945489 | 0.73 | S1PR1 (0.43) | S1PR1S1PR3GLAPOLBGAA | |
| SCHEMBL1802128 | 0.73 | ALOX5 (0.59) | S1PR1S1PR3KIF11AR | |
| SCHEMBL1926441 | 0.73 | TSHR (0.70) | S1PR1S1PR3GLAPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638551-A4 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2008-12-31 | — | — | EP | disclosed |
| EP-1638551-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004103309-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2004-12-02 | — | — | WO | disclosed |