Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219602 | 0.84 | ADRA1A (0.55) | ADRA1AADRA1BKDM4EGLAKMT2A | |
| SCHEMBL10884917 | 0.83 | ADRA1A (0.54) | ADRA1AADRA1BKDM4EGLAKMT2A | |
| SCHEMBL7873424 | 0.83 | ADRA1A (0.54) | ADRA1AADRA1BKDM4EGLAKMT2A | |
| SCHEMBL29814980 | 0.83 | TSHR (0.57) | ADRA1AADRA1BKDM4EKMT2AALDH1A1 | |
| SCHEMBL31518562 | 0.82 | KDM4E (0.57) | ADRA1AADRA1BKDM4EGLAKMT2A | |
| SCHEMBL6197980 | 0.81 | ADRA1A (0.57) | ADRA1AADRA1BKDM4EGLAKMT2A | |
| SCHEMBL1782357 | 0.78 | ALDH1A1 (0.52) | KDM4EKMT2AALDH1A1HTTPOLB | |
| SCHEMBL7439245 | 0.78 | ADRA1A (0.55) | ADRA1AADRA1BKDM4EGLAKMT2A | |
| SCHEMBL1643649 | 0.78 | KDM4E (0.72) | ADRA1AADRA1BKDM4EGLAKMT2A | |
| SCHEMBL7434506 | 0.77 | KDM4E (0.57) | ADRA1AADRA1BKDM4EGLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268525-B1 | MACROCYCLIC NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS COMPRISING N-CYCLIC P2 MOIETIES | SCHERING CORP (US) | 2008-12-31 | — | — | EP | disclosed |
| US-6914122-B2 | Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties | SCHERING CORPORATION (US) | 2005-07-05 | — | — | US | disclosed |
| US-6846802-B2 | Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising N-cyclic P2 moieties | SCHERING CORPORATION (US) | 2005-01-25 | — | — | US | disclosed |
| US-20020107181-A1 | Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising N-cyclic P2 moieties | SCHERING CORPORATION | 2002-08-08 | — | — | US | disclosed |
| US-20020016294-A1 | Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties | SCHERING CORPORATION | 2002-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016294-A1 | Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties | PRSS3, HPN, DPP3 | ADRA1A 4643/4885ADRA1B 4628/4885KDM4E 3002/4885 |
| US-20020107181-A1 | Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising N-cyclic P2 moieties | HPN, TMPRSS15, HAVCR2 | ADRA1A 4768/4885ADRA1B 4774/4885KDM4E 2223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.