Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 13/20 | 0.47 |
| ▸ | TACR2 | P21452 | 10/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4665926 | 0.93 | LMNA (0.48) | TACR3TACR2LMNAOPRM1KCNH2 | |
| SCHEMBL4667076 | 0.93 | LMNA (0.48) | TACR3TACR2LMNAOPRM1KCNH2 | |
| SCHEMBL4667069 | 0.88 | TACR3 (0.47) | TACR3TACR2LMNAOPRM1KCNH2 | |
| SCHEMBL4667106 | 0.85 | LMNA (0.64) | TACR3TACR2LMNATP53ALDH1A1 | |
| SCHEMBL4667478 | 0.83 | LMNA (0.56) | TACR3TACR2LMNATP53ALDH1A1 | |
| SCHEMBL4665944 | 0.82 | TACR3 (0.71) | TACR3TACR2OPRM1 | |
| SCHEMBL6625208 | 0.81 | LMNA (0.53) | TACR3TACR2LMNAOPRM1TP53 | |
| SCHEMBL4668578 | 0.80 | LMNA (0.48) | TACR3TACR2LMNAKCNH2TP53 | |
| SCHEMBL4665278 | 0.79 | LMNA (0.66) | TACR3TACR2LMNAOPRM1TP53 | |
| SCHEMBL7003424 | 0.79 | LMNA (0.50) | TACR3TACR2LMNAOPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940795-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2008-07-09 | — | — | EP | claimed |
| WO-2007035156-A1 | N-OXO-HETEROCYCLE AND N-OXO-ALKYL QUINOLINE-4-CARBOXAMIDES AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | claimed |