Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.49 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.44 |
| ▸ | CDK9 | P50750 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4666195 | 0.88 | TNNI3K (0.50) | TNNI3KPTPN2PTPN1PTPN5MAP4K4 | |
| SCHEMBL4666159 | 0.85 | KMO (0.48) | TNNI3KPGRPTPN2PTPN1PTPN5 | |
| SCHEMBL4667473 | 0.84 | MEN1 (0.51) | TNNI3KMAP4K4CCNT1CDK9CDK1 | |
| SCHEMBL4665695 | 0.83 | CYP1A2 (0.47) | TNNI3KMAP4K4CCNT1CDK9CDK1 | |
| SCHEMBL4666155 | 0.81 | CYP1A2 (0.48) | TNNI3KMAP4K4CCNT1CDK9CDK1 | |
| SCHEMBL4663833 | 0.80 | CYP1A2 (0.47) | PGRPTPN2PTPN1PTPN5MAP4K4 | |
| SCHEMBL4665837 | 0.78 | SLC22A12 (0.50) | PTPN2PTPN1PTPN5CYP1A2CYP3A4 | |
| SCHEMBL4665802 | 0.78 | CYP1A2 (0.50) | MAP4K4CCNT1CDK9CDK1CDK4 | |
| SCHEMBL11939499 | 0.76 | CDK9 (0.64) | TNNI3KMAP4K4CCNT1CDK9CDK1 | |
| SCHEMBL15870338 | 0.75 | CCNT1 (0.65) | CCNT1CDK9ALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242681-A1 | N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors | ALTANA PHARMA AG (DE) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242681-A1 | N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors | MAP3K19, MAP3K6, MAP3K20 | TNNI3K 25/4885PGR 828/4885BRD4 336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.