Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12895145 | 0.74 | GRIN1 (0.39) | POLBSMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL12253328 | 0.74 | POLB (0.42) | POLBSMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL3750599 | 0.73 | ATM (0.43) | POLBSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL1993959 | 0.73 | LMNA (0.49) | POLBLMNA | |
| SCHEMBL2797750 | 0.70 | LMNA (0.43) | POLBSMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL11420042 | 0.69 | POLB (0.50) | POLBSMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL3756960 | 0.69 | CA1 (0.54) | SMN1; SMN2GAARAB9ANPC1TP53 | |
| SCHEMBL7354403 | 0.67 | POLB (1.00) | POLBSMN1; SMN2ALDH1A1LMNATAAR1 | |
| SCHEMBL12567258 | 0.66 | RAB9A (0.42) | POLBSMN1; SMN2LMNATAAR1RAB9A | |
| SCHEMBL9658772 | 0.66 | POLB (0.70) | POLBSMN1; SMN2ALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4861789-A | Dihydro-indene-amine-dihydrooxazoles | BEECHAM GROUP PLC (GB) | 1989-08-29 | — | — | US | claimed |
| EP-0251453-A2 | Substituted amino-dihydrooxazoles, -thiazoles and -imidazoles, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-01-07 | — | — | EP | claimed |
| WO-2008135181-A2 | INSECTICIDAL SUBSTITUTED 2-AMINOINDANES | BAYER CROPSCIENCE AG (DE) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008135181-A2 | INSECTICIDAL SUBSTITUTED 2-AMINOINDANES | BAYER CROPSCIENCE AG (DE) | 2008-11-13 | — | — | WO | disclosed |
| EP-1988080-A1 | Insecticidal substituted 2-aminoindanes | Bayer CropScience AG (DE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1988080-A1 | Insecticidal substituted 2-aminoindanes | Bayer CropScience AG (DE) | 2008-11-05 | — | — | EP | disclosed |
| US-4861789-A | Dihydro-indene-amine-dihydrooxazoles | BEECHAM GROUP PLC (GB) | 1989-08-29 | — | — | US | disclosed |
| EP-0251453-A2 | Substituted amino-dihydrooxazoles, -thiazoles and -imidazoles, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-01-07 | — | — | EP | disclosed |