Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 12/20 | 0.46 |
| ▸ | AURKA | O14965 | 8/20 | 0.46 |
| ▸ | TEK | Q02763 | 6/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | LCK | P06239 | 3/20 | 0.46 |
| ▸ | TPX2 | Q9ULW0 | 5/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668233 | 0.79 | AURKA (0.37) | AURKBAURKATEKTPX2 | |
| SCHEMBL4668332 | 0.78 | AURKB (0.36) | AURKBAURKATEKTPX2ERN1 | |
| SCHEMBL4668267 | 0.76 | TEK (0.46) | AURKBAURKATEKKDRLCK | |
| SCHEMBL580231 | 0.73 | AURKB (0.72) | AURKBAURKATEKKDRLCK | |
| SCHEMBL581299 | 0.73 | TEK (0.42) | AURKBAURKATEKKDRLCK | |
| SCHEMBL4667140 | 0.73 | PDE10A (0.43) | TEKKDR | |
| SCHEMBL4668273 | 0.73 | AURKB (0.48) | AURKBAURKATEKKDRLCK | |
| SCHEMBL580553 | 0.71 | LTA4H (0.36) | AURKBAURKAPRKD3PRKD2 | |
| SCHEMBL4668531 | 0.70 | TEK (0.41) | AURKBAURKATEKKDRLCK | |
| SCHEMBL581733 | 0.69 | AURKB (0.51) | AURKBAURKATEKKDRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |