Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 6/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668233 | 0.85 | AURKA (0.37) | AURKBAURKATPX2PDE10ATEK | |
| SCHEMBL4668268 | 0.81 | AURKB (0.37) | AURKBAURKATPX2PDE10ATEK | |
| SCHEMBL4667173 | 0.78 | AURKB (0.46) | AURKBAURKATPX2TEKMAPK10 | |
| SCHEMBL4667140 | 0.77 | PDE10A (0.43) | PDE10ATEK | |
| SCHEMBL4668267 | 0.75 | TEK (0.46) | AURKBAURKATPX2TEK | |
| SCHEMBL580553 | 0.75 | LTA4H (0.36) | AURKBAURKABRAFKCNH2 | |
| SCHEMBL581299 | 0.73 | TEK (0.42) | AURKBAURKATPX2TEKBRAF | |
| SCHEMBL4668273 | 0.72 | AURKB (0.48) | AURKBAURKATPX2TEK | |
| SCHEMBL4668531 | 0.70 | TEK (0.41) | AURKBAURKATPX2TEK | |
| SCHEMBL581418 | 0.69 | AURKA (0.39) | AURKBAURKATPX2PDE10ATEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |