Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | TEK | Q02763 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668233 | 0.79 | AURKA (0.37) | PDE10ATEK | |
| SCHEMBL4668332 | 0.77 | AURKB (0.36) | PDE10ATEK | |
| SCHEMBL581299 | 0.75 | TEK (0.42) | KDRTEK | |
| SCHEMBL587790 | 0.75 | PDE10A (0.55) | PDE10AKDRTEK | |
| SCHEMBL4668267 | 0.74 | TEK (0.46) | KDRTEK | |
| SCHEMBL4667173 | 0.73 | AURKB (0.46) | KDRTEK | |
| SCHEMBL4668540 | 0.72 | FEN1 (0.33) | PDE10A | |
| SCHEMBL2482411 | 0.71 | — | — | |
| SCHEMBL580553 | 0.71 | LTA4H (0.36) | — | |
| SCHEMBL4668273 | 0.71 | AURKB (0.48) | KDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |