Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.41 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28737418 | 0.82 | LMNA (0.56) | LMNAKDM4EALDH1A1SLC29A1MAOB | |
| SCHEMBL5622214 | 0.81 | KMT2A (0.47) | S1PR5S1PR1KDM4EALDH1A1FUCA1 | |
| SCHEMBL4670377 | 0.78 | ALDH1A1 (0.48) | S1PR5S1PR1ALDH1A1POLBFUCA1 | |
| SCHEMBL3315165 | 0.76 | FUCA1 (0.51) | S1PR5S1PR1ALDH1A1FUCA1 | |
| SCHEMBL4669376 | 0.75 | HRH3 (0.33) | LMNAKDM4EALDH1A1POLBHRH3 | |
| SCHEMBL2968146 | 0.74 | S1PR5 (0.51) | LMNAS1PR5S1PR1KDM4EALDH1A1 | |
| SCHEMBL5072489 | 0.74 | SIGMAR1 (0.47) | S1PR5S1PR1POLBFUCA1CA1 | |
| SCHEMBL5316198 | 0.74 | DRD4 (0.50) | S1PR5S1PR1FUCA1ACHE | |
| Hydrochloric Acid SCHEMBL2966846 | 0.73 | S1PR5 (0.50) | LMNAS1PR5S1PR1KDM4EALDH1A1 | |
| SCHEMBL28737370 | 0.73 | KMT2A (0.57) | LMNAKDM4EALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |