Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | THPO | P40225 | 1/20 | 0.64 |
| ▸ | MTOR | P42345 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10356303 | 0.92 | SLC6A4 (0.70) | SIGMAR1SLC6A4SLC6A3SMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL10552395 | 0.90 | SLC6A4 (0.68) | SIGMAR1SLC6A4SLC6A3SMN1; SMN2CYP1A2 | |
| SCHEMBL10357800 | 0.90 | SIGMAR1 (0.81) | SIGMAR1SLC6A4SLC6A3SMN1; SMN2CYP1A2 | |
| SCHEMBL4728006 | 0.88 | CHRNA7 (0.77) | SIGMAR1SLC6A4SLC6A3SMN1; SMN2CYP1A2 | |
| SCHEMBL4667575 | 0.88 | CYP2D6 (0.58) | SIGMAR1SLC6A4SLC6A3CYP1A2CYP2D6 | |
| SCHEMBL7006203 | 0.85 | TDP1 (0.60) | SLC6A4SLC6A3CYP2D6SLC6A2MAPT | |
| SCHEMBL10559878 | 0.84 | SIGMAR1 (0.69) | SIGMAR1SLC6A4SLC6A3SMN1; SMN2CYP1A2 | |
| SCHEMBL10356356 | 0.83 | SLC6A4 (0.64) | SIGMAR1SLC6A4SLC6A3SMN1; SMN2CYP1A2 | |
| SCHEMBL10356309 | 0.83 | SLC6A4 (0.64) | SIGMAR1SLC6A4SLC6A3SMN1; SMN2CYP1A2 | |
| SCHEMBL10356635 | 0.83 | SLC6A4 (0.64) | SIGMAR1SLC6A4SLC6A3SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1930308-A1 | Pharmaceutical agents for the treatment of cerebral amyloidosis | NYMOX CORPORATION (CA) | 2008-06-11 | — | — | EP | disclosed |
| EP-0983222-B1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORP (CA) | 2007-11-28 | — | — | EP | disclosed |
| EP-0983222-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998052898-A9 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORP (CA) | 1999-04-01 | — | — | WO | disclosed |
| WO-1998052898-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 1998-11-26 | — | — | WO | disclosed |