SCHEMBL4667575

SCHEMBL4667575

FC(F)(F)c1ccc(C(OCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)c2ccccc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.58
CYP3A4 P08684 2/20 0.55
MEN1 O00255 1/20 0.55
CYP2C9 P11712 1/20 0.55
ALOX15 P16050 1/20 0.55
SLC6A1 P30531 1/20 0.55
KMT2A Q03164 1/20 0.55
SIGMAR1 Q99720 1/20 0.54
CACNA1A O00555 1/20 0.54
CACNA2D1 P54289 1/20 0.54
CACNA1B Q00975 1/20 0.54
CACNB1 Q02641 1/20 0.54
CACNA1C Q13936 1/20 0.54
SLC6A4 P31645 2/20 0.53
SLC6A3 Q01959 2/20 0.53
CYP1A2 P05177 1/20 0.53
TSHR P16473 1/20 0.53
CYP2C19 P33261 1/20 0.53
HIF1A Q16665 1/20 0.53
SLC22A1 O15245 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4667624 0.88 SIGMAR1 (0.68) CYP2D6CYP3A4MEN1CYP2C9ALOX15
SCHEMBL10356303 0.86 SLC6A4 (0.70) CYP2D6CYP3A4MEN1CYP2C9KMT2A
Hydrochloric Acid SCHEMBL10552395 0.85 SLC6A4 (0.68) CYP2D6CYP3A4MEN1CYP2C9KMT2A
SCHEMBL10931780 0.81 HRH1 (0.71) CYP2D6KMT2ACACNA1ACACNA2D1CACNA1B
SCHEMBL8098254 0.80 SLC6A4 (0.62) CYP2D6CYP3A4MEN1CYP2C9ALOX15
SCHEMBL10559878 0.80 SIGMAR1 (0.69) CYP2D6CYP3A4MEN1CYP2C9KMT2A
SCHEMBL4667595 0.79 FFAR1 (0.52) CYP2D6CYP3A4MEN1CYP2C9ALOX15
SCHEMBL10928057 0.79 TACR1 (0.62) CYP2D6CACNA1ACACNA2D1CACNA1BCACNB1
SCHEMBL10357800 0.79 SIGMAR1 (0.81) CYP2D6CYP3A4MEN1CYP2C9ALOX15
SCHEMBL10356356 0.79 SLC6A4 (0.64) CYP2D6CYP3A4MEN1CYP2C9KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1930308-A1 Pharmaceutical agents for the treatment of cerebral amyloidosis NYMOX CORPORATION (CA) 2008-06-11 EP disclosed
EP-0983222-B1 PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS NYMOX CORP (CA) 2007-11-28 EP disclosed
WO-1998052898-A9 PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS NYMOX CORP (CA) 1999-04-01 WO disclosed