Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | UGCG | Q16739 | 1/20 | 0.39 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 4/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | CCR3 | P51677 | 2/20 | 0.37 |
| ▸ | HRH2 | P25021 | 3/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669235 | 0.91 | KCNH2 (0.44) | KCNH2CD274HTR1ADRD2HTR7 | |
| SCHEMBL4669237 | 0.87 | KCNH2 (0.52) | KCNH2HRH1HRH2HRH3KCNA5 | |
| SCHEMBL4134193 | 0.86 | KCNH2 (0.53) | KCNH2CD274HRH1HRH2HRH3 | |
| SCHEMBL4125747 | 0.86 | KCNH2 (0.48) | KCNH2CD274DRD2L3MBTL1CNR1 | |
| SCHEMBL1619458 | 0.86 | FAAH (0.46) | KCNH2CD274DRD2DRD3PKM | |
| SCHEMBL4137801 | 0.85 | KCNH2 (0.59) | KCNH2HRH1HRH2HRH3 | |
| SCHEMBL2967590 | 0.85 | KCNH2 (0.44) | KCNH2CD274HTR1ADRD2HTR7 | |
| SCHEMBL5316269 | 0.84 | HTR1A (0.45) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL4668117 | 0.83 | KCNH2 (0.40) | KCNH2CCR5HTR1ADRD2HTR7 | |
| SCHEMBL5316850 | 0.82 | HTR1A (0.49) | HTR1ADRD2HTR7HTR6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | claimed |