Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | HRH2 | P25021 | 7/20 | 0.44 |
| ▸ | HRH1 | P35367 | 7/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4134193 | 0.94 | KCNH2 (0.53) | KCNH2HRH2HRH1HRH3KCNA5 | |
| SCHEMBL4137801 | 0.93 | KCNH2 (0.59) | KCNH2HRH2HRH1HRH3MEN1 | |
| SCHEMBL1619409 | 0.90 | KCNH2 (0.54) | KCNH2HRH2HRH1HRH3KCNA5 | |
| SCHEMBL4139633 | 0.89 | KCNH2 (0.53) | KCNH2HRH2HRH1HRH3KCNA5 | |
| SCHEMBL3598224 | 0.89 | KCNH2 (0.57) | KCNH2HRH2HRH1HRH3MEN1 | |
| SCHEMBL4669235 | 0.88 | KCNH2 (0.44) | KCNH2HRH2HRH1HRH3KDM4E | |
| SCHEMBL4140849 | 0.88 | KCNH2 (0.56) | KCNH2HRH2HRH1HRH3MEN1 | |
| SCHEMBL4668152 | 0.87 | KCNH2 (0.44) | KCNH2HRH2HRH1HRH3KCNA5 | |
| SCHEMBL5314744 | 0.83 | CD274 (0.54) | KCNH2HRH2HRH1HRH3KCNA5 | |
| SCHEMBL4669223 | 0.83 | KCNH2 (0.47) | KCNH2HRH2HRH1HRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |