Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 6/20 | 0.42 |
| ▸ | HRH1 | P35367 | 5/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | HRH2 | P25021 | 4/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668152 | 0.91 | KCNH2 (0.44) | KCNH2HTR1AHRH1OPRM1DRD4 | |
| SCHEMBL4125747 | 0.89 | KCNH2 (0.48) | KCNH2DRD2DRD3CNR1CD274 | |
| SCHEMBL2967590 | 0.89 | KCNH2 (0.44) | KCNH2HTR1AHRH1OPRM1DRD4 | |
| SCHEMBL4669237 | 0.88 | KCNH2 (0.52) | KCNH2HRH1HRH2KDM4EALDH1A1 | |
| SCHEMBL4134193 | 0.85 | KCNH2 (0.53) | KCNH2HRH1HRH2CD274KDM4E | |
| SCHEMBL1619458 | 0.85 | FAAH (0.46) | KCNH2DRD2DRD3CD274ALDH1A1 | |
| SCHEMBL4137801 | 0.84 | KCNH2 (0.59) | KCNH2HRH1HRH2HRH3 | |
| SCHEMBL4669141 | 0.83 | OPRM1 (0.44) | KCNH2HTR1AHRH1OPRM1DRD4 | |
| SCHEMBL1619409 | 0.81 | KCNH2 (0.54) | KCNH2HRH1HRH2HRH3 | |
| SCHEMBL5318392 | 0.81 | CD274 (0.58) | KCNH2DRD2DRD3SIGMAR1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |