Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 1.00 |
| ▸ | HTR1A | P08908 | 5/20 | 0.68 |
| ▸ | HTR2C | P28335 | 3/20 | 0.68 |
| ▸ | CCR3 | P51677 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8110473 | 0.93 | SIGMAR1 (1.00) | SIGMAR1HTR1AHTR2CCCR3 | |
| SCHEMBL8870940 | 0.90 | SIGMAR1 (0.82) | SIGMAR1HTR1AHTR2C | |
| SCHEMBL8100660 | 0.86 | SIGMAR1 (1.00) | SIGMAR1HTR1AHTR2C | |
| SCHEMBL7759816 | 0.84 | SIGMAR1 (1.00) | SIGMAR1HTR1AHTR2C | |
| SCHEMBL8116065 | 0.79 | HTR1A (0.67) | SIGMAR1HTR1AHTR2CCCR3 | |
| SCHEMBL8117008 | 0.79 | SIGMAR1 (1.00) | SIGMAR1HTR1AHTR2C | |
| SCHEMBL8870163 | 0.78 | SIGMAR1 (0.64) | SIGMAR1HTR1ACCR3 | |
| SCHEMBL7759846 | 0.77 | SIGMAR1 (1.00) | SIGMAR1HTR1AHTR2C | |
| SCHEMBL9449586 | 0.76 | SIGMAR1 (0.69) | SIGMAR1HTR1AHTR2C | |
| SCHEMBL8870387 | 0.76 | SIGMAR1 (0.61) | SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673933-B1 | Aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and compositions containing them | ADIR (FR) | 2000-11-08 | — | — | EP | claimed |
| US-5688811-A | PSYCHOLOGICAL DISORDERS; NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-11-18 | — | — | US | claimed |
| EP-0673933-A1 | Aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-09-27 | — | — | EP | claimed |
| EP-2600863-B1 | USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA | ESTEVE LABOR DR (ES) | 2018-03-28 | — | — | EP | disclosed |
| EP-2646025-B1 | USE OF SIGMA LIGANDS IN BONE CANCER PAIN | ESTEVE LABOR DR (ES) | 2017-03-15 | — | — | EP | disclosed |
| EP-2531191-B1 | Sigma ligands for use in the prevention and/or treatment of postoperative pain | ESTEVE LABOR DR (ES) | 2016-03-30 | — | — | EP | disclosed |
| EP-2571501-B1 | SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY | ESTEVE LABOR DR (ES) | 2016-03-02 | — | — | EP | disclosed |
| EP-2460519-A1 | Use of sigma ligands in bone cancer pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-06-06 | — | — | EP | disclosed |
| EP-2415471-A1 | Use of sigma ligands in opioid-induced hyperalgesia | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-02-08 | — | — | EP | disclosed |
| EP-2388005-A1 | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-11-23 | — | — | EP | disclosed |
| EP-2353598-A1 | Sigma ligands for use in the prevention and/or treatment of postoperative pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-08-10 | — | — | EP | disclosed |
| EP-0673933-B1 | Aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and compositions containing them | ADIR (FR) | 2000-11-08 | — | — | EP | disclosed |
| US-5688820-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-11-18 | — | — | US | disclosed |
| US-5688811-A | PSYCHOLOGICAL DISORDERS; NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-11-18 | — | — | US | disclosed |
| US-5534511-A | AFFINITY FOR SIGMA RECEPTORS, ANTIINFLAMMATORY, TREATMENT OF ARTHRITIS | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| EP-0673933-A1 | Aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-09-27 | — | — | EP | disclosed |