Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4823521 | 0.98 | TNF (0.37) | TNFKMT2AUSP2CHRNB2CHRNA3 | |
| SCHEMBL4818195 | 0.85 | KCNQ3 (0.41) | TNFKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL4672927 | 0.79 | MAPKAPK2 (0.36) | KMT2AMEN1ALDH1A1LMNAKCNQ3 | |
| SCHEMBL4670847 | 0.78 | TNF (0.38) | TNFCHRNB2KCNQ3KCNQ2KCNE1 | |
| SCHEMBL31247581 | 0.74 | KDM4E (0.38) | TNFALDH1A1KCNQ3KCNQ2KCNE1 | |
| SCHEMBL4669084 | 0.73 | RAB9A (0.46) | CHRNB2ALDH1A1CHRNA4 | |
| SCHEMBL4442545 | 0.72 | ADRA2A (0.49) | TNFKMT2AMEN1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL4825575 | 0.72 | RAB9A (0.45) | CHRNB2CHRNA4 | |
| SCHEMBL4669089 | 0.70 | POLB (0.35) | KMT2ACHRNB2CHRNA3CHRNA7MEN1 | |
| SCHEMBL4818188 | 0.70 | KCNQ3 (0.43) | TNFALDH1A1KCNQ3KCNQ2KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1757586-B1 | POLYSBUSTITUIRTE 1,1-PYRIDINYLAMINOCYCLOPROPANAMIN DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE ENTHALTENDE PHARMATUETISCHE ZUSAMMENSETZUNG | SERVIER LAB (FR) | 2008-12-03 | — | — | EP | disclosed |
| EP-1757586-A1 | POLYSBUSTITUIRTE 1,1-PYRIDINYLAMINOCYCLOPROPANAMIN DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE ENTHALTENDE PHARMATUETISCHE ZUSAMMENSETZUNG | Les Laboratoires Servier (FR) | 2007-02-28 | — | — | EP | disclosed |