Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.43 |
| ▸ | HRH2 | P25021 | 11/20 | 0.43 |
| ▸ | HRH1 | P35367 | 11/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669141 | 0.87 | OPRM1 (0.44) | KCNH2KCNA5HRH3HRH2HRH1 | |
| SCHEMBL4668117 | 0.86 | KCNH2 (0.40) | KCNH2KCNA5HRH3HRH2HRH1 | |
| SCHEMBL4669237 | 0.83 | KCNH2 (0.52) | KCNH2KCNA5HRH3HRH2HRH1 | |
| SCHEMBL5534239 | 0.83 | KCNH2 (0.43) | KCNH2KCNA5HRH3HRH2HRH1 | |
| SCHEMBL2966798 | 0.81 | KCNH2 (0.53) | KCNH2KCNA5HRH3HRH2HRH1 | |
| SCHEMBL2954545 | 0.81 | KCNH2 (0.48) | KCNH2HRH3HRH2HRH1 | |
| SCHEMBL1619682 | 0.79 | KCNH2 (0.45) | KCNH2KCNA5HRH3HRH2HRH1 | |
| SCHEMBL2968099 | 0.79 | KCNA5 (0.54) | KCNH2KCNA5HRH3HRH2HRH1 | |
| SCHEMBL3129013 | 0.78 | KCNH2 (0.55) | KCNH2HRH3HRH2HRH1 | |
| SCHEMBL3119483 | 0.78 | KCNH2 (0.52) | KCNH2KCNA5HRH3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | claimed |