Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | HRH1 | P35367 | 4/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | HRH2 | P25021 | 3/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668117 | 0.90 | KCNH2 (0.40) | OPRM1HTR1AHRH1DRD4HTR2A | |
| SCHEMBL4669223 | 0.87 | KCNH2 (0.47) | HRH1HRH2KCNH2KCNA5HRH3 | |
| SCHEMBL4669235 | 0.83 | KCNH2 (0.44) | OPRM1HTR1AHRH1DRD4HTR2A | |
| SCHEMBL5533438 | 0.82 | HTR1A (0.38) | OPRM1HTR1AHRH1DRD4HTR2A | |
| SCHEMBL1619372 | 0.79 | HTR1A (0.39) | OPRM1HTR1AHRH1DRD4HTR2A | |
| SCHEMBL2967582 | 0.75 | KCNH2 (0.52) | HRH1HRH2KCNH2KCNJ1KCNA5 | |
| SCHEMBL5534239 | 0.75 | KCNH2 (0.43) | HRH1HRH2KCNH2KCNA5HRH3 | |
| SCHEMBL5319731 | 0.74 | KCNH2 (0.44) | DRD2DRD3KCNH2KCNJ1L3MBTL1 | |
| SCHEMBL4668152 | 0.74 | KCNH2 (0.44) | OPRM1HTR1AHRH1DRD4HTR2A | |
| SCHEMBL2962586 | 0.73 | HTR1A (0.47) | OPRM1HTR1AHRH1DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | claimed |