Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.49 |
| ▸ | BRD1 | O95696 | 4/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4673715 | 0.99 | ADRB2 (0.48) | ADRB2ADRB1ADRB3BRD1BRPF1 | |
| SCHEMBL4672288 | 0.99 | ADRB2 (0.48) | ADRB2ADRB1ADRB3BRD1BRPF1 | |
| SCHEMBL14143274 | 0.88 | ADRB2 (0.47) | ADRB2ADRB1ADRB3BRD1BRPF1 | |
| SCHEMBL14143417 | 0.88 | ADRB2 (0.47) | ADRB2ADRB1ADRB3BRD1BRPF1 | |
| SCHEMBL4670517 | 0.85 | ADRB2 (0.49) | ADRB2ADRB1ADRB3BRD1BRPF1 | |
| SCHEMBL4672064 | 0.79 | ADRB2 (0.49) | ADRB2ADRB1ADRB3BRD1BRPF1 | |
| SCHEMBL14143419 | 0.78 | ADRB2 (0.70) | ADRB2ADRB1ADRB3 | |
| SCHEMBL4673203 | 0.74 | ADRB2 (0.47) | ADRB2ADRB1ADRB3BRD1BRPF1 | |
| SCHEMBL4675636 | 0.73 | PKM (0.64) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14143369 | 0.73 | ADRB2 (0.48) | ADRB2ADRB1ADRB3BRD1BRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054881-B1 | NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS | BAYER CORP (US) | 2008-07-30 | — | — | EP | disclosed |
| US-6903218-B2 | Sulfonamide substituted chroman derivatives | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-06-07 | — | — | US | disclosed |
| US-20040072843-A1 | Novel sulfonamide substituted chroman derivatives useful as beta 3 adrenoreceptor agonists | LADOUCEUR GAETAN H (US) | 2004-04-15 | — | — | US | disclosed |
| US-20030073839-A1 | Compounds useful for preparation of Beta-3 adrenoreceptor agonist | BAYER PHARMACEUTICALS CORPORATION | 2003-04-17 | — | — | US | disclosed |
| US-6051586-A | HYPOGLYCEMIC AGENTS; ANTIDIABETIC AGENTS | BAYER CORPORATION (US) | 2000-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072843-A1 | Novel sulfonamide substituted chroman derivatives useful as beta 3 adrenoreceptor agonists | ADRB3, ADRB2, ADRB1 | ADRB2 2/4885ADRB1 3/4885ADRB3 1/4885 |
| US-20030073839-A1 | Compounds useful for preparation of Beta-3 adrenoreceptor agonist | ADRB3, ADRB2, ADRB1 | ADRB2 2/4885ADRB1 3/4885ADRB3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.