Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PNMT | P11086 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729495 | 0.88 | MAPT (0.49) | PKMMAPTLMNASMN1; SMN2HDAC3 | |
| SCHEMBL4672292 | 0.82 | HPGD (0.50) | PKMMAPTLMNASMN1; SMN2 | |
| SCHEMBL4672139 | 0.80 | CYP4F2 (0.41) | PKMMAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL1064265 | 0.79 | CYP4F2 (0.44) | SMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL29586898 | 0.78 | MAPT (0.44) | PKMMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL4670404 | 0.73 | ADRB2 (0.49) | PKMMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL4672288 | 0.73 | ADRB2 (0.48) | PKMMAPTLMNAHDAC3HDAC4 | |
| SCHEMBL5839879 | 0.72 | ESR1 (0.56) | HDAC3HDAC1HDAC2 | |
| SCHEMBL29587651 | 0.70 | LMNA (0.43) | PKMMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL4672067 | 0.70 | CYP4F2 (0.45) | LMNASMN1; SMN2HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054881-B1 | NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS | BAYER CORP (US) | 2008-07-30 | — | — | EP | disclosed |