Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CPS1 | P31327 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1836446 | 0.98 | CES2 (0.50) | CES2CES1L3MBTL1MEN1KMT2A | |
| Fumaric Acid SCHEMBL10637939 | 0.91 | SLC6A2 (0.50) | CES2CES1L3MBTL1MEN1KMT2A | |
| Fumaric Acid SCHEMBL10637950 | 0.91 | SLC6A2 (0.50) | CES2CES1L3MBTL1MEN1KMT2A | |
| SCHEMBL6141006 | 0.90 | L3MBTL1 (0.61) | CES2CES1L3MBTL1MEN1KMT2A | |
| SCHEMBL20524724 | 0.87 | CES2 (0.52) | CES2CES1L3MBTL1MEN1KMT2A | |
| SCHEMBL30323082 | 0.87 | CES2 (0.52) | CES2CES1L3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL15567881 | 0.85 | CES2 (0.50) | CES2CES1L3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL31196625 | 0.85 | CES2 (0.50) | CES2CES1L3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10964891 | 0.84 | MEN1 (0.46) | CES2CES1L3MBTL1MEN1KMT2A | |
| SCHEMBL226059 | 0.84 | HSD11B1 (0.54) | MEN1KMT2AALDH1A1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118641654-B | Method for detecting related substances of 4- (2, 4-difluorobenzoyl) -piperidine hydrochloride serving as initial raw material of paliperidone | 山东泰合医药科技有限公司 | 2024-12-17 | — | — | CN | claimed |
| CN-118641654-A | Method for detecting related substances of 4- (2, 4-difluorobenzoyl) -piperidine hydrochloride serving as initial raw material of paliperidone | 山东泰合医药科技有限公司 | 2024-09-13 | — | — | CN | claimed |
| CN-118561742-A | Rupestonic acid amide derivative containing nitrogen heterocycle, and preparation method and application thereof | 中国科学院新疆理化技术研究所 | 2024-08-30 | — | — | CN | claimed |
| CN-115057809-B | Preparation method of 4- (2, 4-difluorobenzoyl) -piperidine | 扬州市普林斯医药科技有限公司 | 2024-02-13 | — | — | CN | claimed |
| CN-115057809-A | Preparation method of 4- (2, 4-difluorobenzoyl) -piperidine | 扬州市普林斯医药科技有限公司 | 2022-09-16 | — | — | CN | claimed |
| CN-106831742-B | A kind of preparation method of Iloperidone intermediate | 北京医药集团有限责任公司 | 2019-08-23 | — | — | CN | claimed |
| CN-106831742-A | A kind of preparation method of Iloperidone intermediate | 北京医药集团有限责任公司 | 2017-06-13 | — | — | CN | claimed |
| CN-102796090-B | Method for preparing iloperidone | TIANJIN HUAJIN PHARMACEUTICAL CO LTD | 2015-03-25 | — | — | CN | claimed |
| US-4408053-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-10-04 | — | — | US | claimed |
| CN-118641654-B | Method for detecting related substances of 4- (2, 4-difluorobenzoyl) -piperidine hydrochloride serving as initial raw material of paliperidone | 山东泰合医药科技有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-118641654-A | Method for detecting related substances of 4- (2, 4-difluorobenzoyl) -piperidine hydrochloride serving as initial raw material of paliperidone | 山东泰合医药科技有限公司 | 2024-09-13 | — | — | CN | disclosed |
| CN-118561742-A | Rupestonic acid amide derivative containing nitrogen heterocycle, and preparation method and application thereof | 中国科学院新疆理化技术研究所 | 2024-08-30 | — | — | CN | disclosed |
| CN-115057809-B | Preparation method of 4- (2, 4-difluorobenzoyl) -piperidine | 扬州市普林斯医药科技有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-115057809-B | Preparation method of 4- (2, 4-difluorobenzoyl) -piperidine | 扬州市普林斯医药科技有限公司 | 2024-02-13 | — | — | CN | disclosed |
| US-5100902-A | Dopamine and Serotonin Antagonists, Antipsychotic Agents | ADIR ET COMPAGNIE (FR) | 1992-03-31 | — | — | US | disclosed |
| EP-0428437-A1 | 1,2-Benzisoxazole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-05-22 | — | — | EP | disclosed |
| CN-1049161-A | Heterogeneous ring compound with serotonine 2-receptor antagonistic activity | DAIICHI SEIYAKU CO (JP) | 1991-02-13 | — | — | CN | disclosed |
| EP-0401707-A1 | Heterocyclic triazin or triazolo compounds having serotonin 2-receptor antagonistic activity | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-12 | — | — | EP | disclosed |
| US-4804663-A | PSYCHOLOGICAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-02-14 | — | — | US | disclosed |
| EP-0196132-A2 | 1,2-Benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-10-01 | — | — | EP | disclosed |