Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E known ✓ | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B known ✓ | O95264 | 1/20 | 0.46 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D known ✓ | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C known ✓ | Q8WXA8 | 1/20 | 0.46 |
| ▸ | HSD11B1 known ✓ | P28845 | 1/20 | 0.40 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | CPS1 | P31327 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672830 | 0.98 | CES2 (0.52) | CES2CES1L3MBTL1MEN1KMT2A | |
| Fumaric Acid SCHEMBL10637939 | 0.90 | SLC6A2 (0.50) | CES2CES1L3MBTL1MEN1KMT2A | |
| Fumaric Acid SCHEMBL10637950 | 0.90 | SLC6A2 (0.50) | CES2CES1L3MBTL1MEN1KMT2A | |
| SCHEMBL6141006 | 0.88 | L3MBTL1 (0.61) | CES2CES1L3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL31196625 | 0.87 | CES2 (0.50) | CES2CES1L3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL15567881 | 0.87 | CES2 (0.50) | CES2CES1L3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10964891 | 0.86 | MEN1 (0.46) | CES2CES1L3MBTL1MEN1KMT2A | |
| SCHEMBL30323082 | 0.85 | CES2 (0.52) | CES2CES1L3MBTL1MEN1KMT2A | |
| SCHEMBL20524724 | 0.85 | CES2 (0.52) | CES2CES1L3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11617261 | 0.84 | MEN1 (0.60) | MEN1KMT2ACYP2D6HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119552159-A | Preparation method of paliperidone | 泰山学院 | 2025-03-04 | — | — | CN | claimed |
| CN-118641654-B | Method for detecting related substances of 4- (2, 4-difluorobenzoyl) -piperidine hydrochloride serving as initial raw material of paliperidone | 山东泰合医药科技有限公司 | 2024-12-17 | — | — | CN | claimed |
| CN-118641654-A | Method for detecting related substances of 4- (2, 4-difluorobenzoyl) -piperidine hydrochloride serving as initial raw material of paliperidone | 山东泰合医药科技有限公司 | 2024-09-13 | — | — | CN | claimed |
| CN-111393425-B | Preparation method of 6-fluoro-3-piperidine-4-yl-1, 2-benzisoxazole hydrochloride | 浙江京新药业股份有限公司 | 2021-11-26 | — | — | CN | claimed |
| CN-111777601-B | Preparation method of 6-fluoro-3- (4-piperidyl) -1, 2 benzisoxazole hydrochloride | 白银京宇新药业有限公司 | 2021-07-16 | — | — | CN | claimed |
| CN-111777601-A | Preparation method of 6-fluoro-3- (4-piperidyl) -1, 2 benzisoxazole hydrochloride | 白银京宇新药业有限公司 | 2020-10-16 | — | — | CN | claimed |
| CN-111393425-A | Preparation method of 6-fluoro-3-piperidine-4-yl-1, 2-benzisoxazole hydrochloride | 浙江京新药业股份有限公司 | 2020-07-10 | — | — | CN | claimed |
| CN-121692955-A | Perovskite solar cell based on fluorine-containing piperidine hydrochloride modified buried bottom interface and preparation method thereof | 海南大学 | 2026-03-17 | — | — | CN | disclosed |
| CN-119552159-A | Preparation method of paliperidone | 泰山学院 | 2025-03-04 | — | — | CN | disclosed |
| CN-118641654-B | Method for detecting related substances of 4- (2, 4-difluorobenzoyl) -piperidine hydrochloride serving as initial raw material of paliperidone | 山东泰合医药科技有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-118641654-B | Method for detecting related substances of 4- (2, 4-difluorobenzoyl) -piperidine hydrochloride serving as initial raw material of paliperidone | 山东泰合医药科技有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-118641654-B | Method for detecting related substances of 4- (2, 4-difluorobenzoyl) -piperidine hydrochloride serving as initial raw material of paliperidone | 山东泰合医药科技有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-118641654-A | Method for detecting related substances of 4- (2, 4-difluorobenzoyl) -piperidine hydrochloride serving as initial raw material of paliperidone | 山东泰合医药科技有限公司 | 2024-09-13 | — | — | CN | disclosed |
| WO-1996035713-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER, INC. (US) | 1996-11-14 | — | — | WO | disclosed |
| EP-0686632-A1 | BENZOTHIAZINE DERIVATIVE | SUNTORY LIMITED (JP) | 1995-12-13 | — | — | EP | disclosed |
| EP-0557289-A1 | 4-(1,2-BENZISOXAZOLYL)PIPERIDINE ANTIPSYCHOTIC AGENTS. | PFIZER (US) | 1993-09-01 | — | — | EP | disclosed |
| EP-0196132-B1 | 1,2-BENZISOXAZOL-3-YL AND 1,2-BENZISOTHIAZOL-3-YL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-12 | — | — | EP | disclosed |
| WO-1992008718-A1 | 4-(1,2-BENZISOXAZOLYL)PIPERIDINE ANTIPSYCHOTIC AGENTS | PFIZER INC. (US) | 1992-05-29 | — | — | WO | disclosed |
| US-4804663-A | PSYCHOLOGICAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-02-14 | — | — | US | disclosed |
| EP-0196132-A2 | 1,2-Benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-10-01 | — | — | EP | disclosed |