Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 9/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 9/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | FPR3 | P25089 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4793424 | 0.88 | FPR2 (0.34) | FPR3FPR2 | |
| SCHEMBL4670888 | 0.67 | — | — | |
| SCHEMBL4672927 | 0.67 | MAPKAPK2 (0.36) | GAAKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL4670847 | 0.66 | TNF (0.38) | GAAKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL4669439 | 0.65 | — | — | |
| SCHEMBL4818195 | 0.65 | KCNQ3 (0.41) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL3980865 | 0.64 | KDM4E (0.53) | RAB9A | |
| SCHEMBL4818188 | 0.64 | KCNQ3 (0.43) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL4669026 | 0.63 | TNF (0.38) | KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL4673434 | 0.63 | GRM5 (0.37) | KCNQ3KCNQ2FPR3FPR2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1757586-B1 | POLYSBUSTITUIRTE 1,1-PYRIDINYLAMINOCYCLOPROPANAMIN DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE ENTHALTENDE PHARMATUETISCHE ZUSAMMENSETZUNG | SERVIER LAB (FR) | 2008-12-03 | — | — | EP | disclosed |
| EP-1757586-A1 | POLYSBUSTITUIRTE 1,1-PYRIDINYLAMINOCYCLOPROPANAMIN DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE ENTHALTENDE PHARMATUETISCHE ZUSAMMENSETZUNG | Les Laboratoires Servier (FR) | 2007-02-28 | — | — | EP | disclosed |