Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8819343 | 0.99 | CHRNA7 (0.51) | CHRNA7DRD2DRD3HRH3METAP1 | |
| SCHEMBL7438546 | 0.85 | HTR2C (0.53) | HRH3HTR2C | |
| SCHEMBL6936516 | 0.84 | CHRNA7 (0.50) | CHRNA7METAP1 | |
| Hydrochloric Acid SCHEMBL7435018 | 0.84 | HTR2C (0.52) | HRH3HTR2C | |
| SCHEMBL7309877 | 0.82 | DRD2 (0.46) | CHRNA7DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL466933 | 0.81 | KMT2A (0.44) | CHRNA7DRD2HTR2C | |
| SCHEMBL7315071 | 0.81 | KMT2A (0.44) | CHRNA7DRD2HTR2C | |
| SCHEMBL466934 | 0.81 | KMT2A (0.44) | CHRNA7DRD2HTR2C | |
| Hydrochloric Acid SCHEMBL467145 | 0.80 | KMT2A (0.43) | CHRNA7DRD2HTR2C | |
| Hydrochloric Acid SCHEMBL8419734 | 0.80 | KMT2A (0.43) | CHRNA7DRD2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7252218-A | — | — | None | — | — | JP | disclosed |
| EP-2600863-B1 | USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA | ESTEVE LABOR DR (ES) | 2018-03-28 | — | — | EP | disclosed |
| EP-2646025-B1 | USE OF SIGMA LIGANDS IN BONE CANCER PAIN | ESTEVE LABOR DR (ES) | 2017-03-15 | — | — | EP | disclosed |
| EP-2531191-B1 | Sigma ligands for use in the prevention and/or treatment of postoperative pain | ESTEVE LABOR DR (ES) | 2016-03-30 | — | — | EP | disclosed |
| EP-2571501-B1 | SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY | ESTEVE LABOR DR (ES) | 2016-03-02 | — | — | EP | disclosed |
| EP-2460519-A1 | Use of sigma ligands in bone cancer pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-06-06 | — | — | EP | disclosed |
| EP-2415471-A1 | Use of sigma ligands in opioid-induced hyperalgesia | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-02-08 | — | — | EP | disclosed |
| EP-2388005-A1 | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-11-23 | — | — | EP | disclosed |
| EP-2353598-A1 | Sigma ligands for use in the prevention and/or treatment of postoperative pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-08-10 | — | — | EP | disclosed |
| US-5538985-A | SIDE EFFECT REDUCTION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1996-07-23 | — | — | US | disclosed |
| JP-H07252218-A | PYRROLIDINONE DERIVATIVE | MITSUI TOATSU CHEM INC | 1995-10-03 | — | — | JP | disclosed |
| EP-0668275-A1 | Pyrrolidinone derivatives | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1995-08-23 | — | — | EP | disclosed |