Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 6/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314254 | 0.85 | DRD2 (0.43) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7305622 | 0.82 | HTR2A (0.41) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL466933 | 0.82 | KMT2A (0.44) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL466934 | 0.82 | KMT2A (0.44) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7315071 | 0.82 | KMT2A (0.44) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL467338 | 0.82 | CHRNA7 (0.52) | DRD2ALDH1A1DRD3CHRNA7KDM4E | |
| Hydrochloric Acid SCHEMBL8419734 | 0.81 | KMT2A (0.43) | DRD2HTR1AHTR2AHTR7HTR6 | |
| Hydrochloric Acid SCHEMBL7311725 | 0.81 | KMT2A (0.43) | DRD2HTR1AHTR2AHTR7HTR6 | |
| Hydrochloric Acid SCHEMBL467146 | 0.81 | KMT2A (0.43) | DRD2HTR1AHTR2AHTR7HTR6 | |
| Hydrochloric Acid SCHEMBL467145 | 0.81 | KMT2A (0.43) | DRD2HTR1AHTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839805-B1 | Pyrrolidinone derivatives and their use as antipsychotic medicaments | SCHERING AG (DE) | 2001-10-04 | — | — | EP | disclosed |
| US-5969138-A | ANTIPSYCHOTIC AGENTS | MITSUI CHEMICALS, INC. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0839805-A1 | Pyrrolidinone derivatives and their use as antipsychotic medicaments | MITSUI TOATSU CHEMICALS, INC. (JP) | 1998-05-06 | — | — | EP | disclosed |