Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4674253 | 0.85 | HTR6 (0.59) | MAPK1PRKDCCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL4673297 | 0.84 | MAPT (0.50) | LTA4HKDM4EMAOAMEN1KMT2A | |
| SCHEMBL4676358 | 0.83 | ITGB3 (0.43) | PRKDCFGFR1LTA4HKDM4E | |
| SCHEMBL28048524 | 0.81 | MAPK1 (0.64) | MAPK1CYP19A1CYP11B1CYP11B2CYP2D6 | |
| SCHEMBL4674738 | 0.75 | CYP3A4 (0.56) | PRKDCFGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7311175 | 0.74 | MAPK1 (0.65) | MAPK1GPR132IKBKBMEN1KMT2A | |
| SCHEMBL10755327 | 0.74 | ALOX5 (0.47) | MAPK1PRKDCCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL171895 | 0.73 | MAPK1 (0.56) | MAPK1CYP19A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL8881389 | 0.73 | HTT (0.62) | MAPK1CYP19A1CYP11B1CYP11B2KDM4E | |
| SCHEMBL8361615 | 0.73 | MAPK1 (0.56) | MAPK1CYP19A1CYP11B1CYP11B2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |