Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.59 |
| ▸ | NMT1 | P30419 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4674249 | 0.85 | MAPK1 (0.47) | HTR6LTA4HFGFR1MAPK1PRKDC | |
| SCHEMBL4676367 | 0.83 | ADRB2 (0.60) | PRMT5LTA4HHTR3EHTR3BADRB1 | |
| SCHEMBL335477 | 0.83 | LTA4H (0.64) | HTR6ALDH1A1PRMT5LTA4HMAPT | |
| Hydrochloric Acid SCHEMBL2156238 | 0.82 | LTA4H (0.62) | HTR6ALDH1A1PRMT5LTA4HMAPT | |
| SCHEMBL28048524 | 0.80 | MAPK1 (0.64) | ALDH1A1HTTMAPK1CYP19A1CYP11B1 | |
| SCHEMBL5230479 | 0.78 | LTA4H (0.57) | HTR6CHRNB2CHRNA4ALDH1A1PRMT5 | |
| SCHEMBL6014772 | 0.78 | HTR6 (0.58) | HTR6NMT1CHRNB2CHRNA4PDE3B | |
| SCHEMBL905960 | 0.76 | HTR2C (0.70) | HTR6NMT1CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL29664303 | 0.76 | HTR6 (0.58) | HTR6NMT1CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL6100222 | 0.76 | HTR6 (0.58) | HTR6NMT1CHRNB2CHRNA4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |