Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5584678 | 0.82 | LMNA (0.75) | LMNARECQLKMT2AALDH1A1RAB9A | |
| SCHEMBL7367818 | 0.77 | LMNA (0.68) | LMNARECQLKMT2AALDH1A1RAB9A | |
| SCHEMBL3061600 | 0.77 | LMNA (0.49) | LMNARECQLKMT2AALDH1A1RAB9A | |
| SCHEMBL10954630 | 0.76 | CHRNB2 (0.50) | LMNARECQLKMT2AALDH1A1RAB9A | |
| SCHEMBL5565438 | 0.76 | LMNA (0.55) | LMNARECQLKMT2AALDH1A1RAB9A | |
| SCHEMBL4674251 | 0.76 | LMNA (0.53) | LMNARECQLKMT2AALDH1A1RAB9A | |
| SCHEMBL3076627 | 0.75 | LMNA (0.51) | LMNARECQLKMT2AALDH1A1RAB9A | |
| SCHEMBL10649682 | 0.75 | LMNA (0.68) | LMNARECQLKMT2AALDH1A1RAB9A | |
| SCHEMBL29902834 | 0.75 | LMNA (0.68) | LMNARECQLKMT2AALDH1A1RAB9A | |
| SCHEMBL5386199 | 0.74 | LMNA (0.52) | LMNARECQLKMT2AALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594864-B1 | BENZOFURAN OXYETHYLAMINES SERVING AS ANTIDEPRESSANT DRUGS AND ANXIOLYTIC DRUGS | MERCK PATENT GMBH (DE) | 2008-10-22 | — | — | EP | disclosed |
| US-7425574-B2 | e.g. 4-{2-[4-(5-cyano-1H-indol-3-yl)butylamino]ethoxy}benzofuran-2-carboxylic acid methyl ester; serotonin 5 HT1A and 5HT1D receptors agonist and antagonist, serotonin reuptake inhibitor; neuroleptic and hypotensive agent; | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-09-16 | — | — | US | disclosed |
| US-7425574-B2 | e.g. 4-{2-[4-(5-cyano-1H-indol-3-yl)butylamino]ethoxy}benzofuran-2-carboxylic acid methyl ester; serotonin 5 HT1A and 5HT1D receptors agonist and antagonist, serotonin reuptake inhibitor; neuroleptic and hypotensive agent; | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-09-16 | — | — | US | disclosed |
| US-7425574-B2 | e.g. 4-{2-[4-(5-cyano-1H-indol-3-yl)butylamino]ethoxy}benzofuran-2-carboxylic acid methyl ester; serotonin 5 HT1A and 5HT1D receptors agonist and antagonist, serotonin reuptake inhibitor; neuroleptic and hypotensive agent; | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-09-16 | — | — | US | disclosed |
| US-20060084693-A1 | Benzofuran oxyethylamines as antidepressants and anxiolytics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-04-20 | — | — | US | disclosed |
| EP-1594864-A1 | BENZOFURAN OXYETHYLAMINES SERVING AS ANTIDEPRESSANT DRUGS AND ANXIOLYTIC DRUGS | MERCK PATENT GmbH (DE) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004074281-A1 | BENZOFURAN OXYETHYLAMINES SERVING AS ANTIDEPRESSANT DRUGS AND ANXIOLYTIC DRUGS | MERCK PATENT GMBH (DE) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084693-A1 | Benzofuran oxyethylamines as antidepressants and anxiolytics | HTR1D, HTR1A, HTR1F | LMNA 1592/4885RECQL 1842/4885KMT2A 901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.