Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HTR1D | P28221 | 7/20 | 0.42 |
| ▸ | HTR1B | P28222 | 5/20 | 0.42 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448712 | 1.00 | DRD2 (0.46) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL7447466 | 0.94 | OPRM1 (0.53) | DRD2SLC6A4OPRM1OPRK1OPRL1 | |
| SCHEMBL4675424 | 0.94 | OPRM1 (0.53) | DRD2SLC6A4OPRM1OPRK1OPRL1 | |
| SCHEMBL4670906 | 0.79 | HSD11B1 (0.49) | DRD2OPRM1OPRK1OPRL1HTR1A | |
| SCHEMBL4671507 | 0.79 | HSD11B1 (0.46) | DRD2OPRM1OPRK1OPRL1HTR1A | |
| SCHEMBL4675645 | 0.78 | HSD11B1 (0.52) | DRD2SLC6A4OPRM1OPRK1OPRL1 | |
| SCHEMBL4671384 | 0.77 | HSD11B1 (0.47) | SLC6A4HTR2AOPRM1OPRK1OPRL1 | |
| SCHEMBL4670881 | 0.77 | HSD11B1 (0.46) | DRD2OPRM1OPRK1OPRL1HTR1A | |
| SCHEMBL4676633 | 0.77 | KDM4E (0.45) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL4671070 | 0.75 | MMP1 (0.49) | HTR7OPRM1OPRK1OPRL1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |